(1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

Base Information

• Chemical Name: (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt
• CAS No.: 677743-79-2
• Molecular Formula: C₆H₁₃N*ClH
• Molecular Weight: 135.637
• Mol file: 677743-79-2.mol

Synonyms:(1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

Chemical Property of (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(1R)-1-cyclobutylethan-1-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

There total 6 articles about (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-[(1R)-1-cyclobutylethyl]-2-methylpropane-2-sulfinamide (1616372-27-0) → (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt (677743-79-2,1355969-30-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 2h;

Reference yield:

cyclobutylaldehyde (2987-17-9) → (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt (677743-79-2,1355969-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(II) sulfate / dichloromethane; Petroleum ether / 48 h / 20 °C / Large scale

2: tetrahydrofuran; diethyl ether / 6 h / -78 - -40 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 20 °C

With hydrogenchloride; copper(II) sulfate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; Petroleum ether;

Reference yield:

C9H17NOS → (1R)-1-cyclobutylethan-1-amine hydrogen chloride salt (677743-79-2,1355969-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane; diethyl ether / 20 h / -61 - 23 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;

DOI:10.1021/acsmedchemlett.8b00296

upstream raw materials:

cyclobutylaldehyde

(S)-N-[(1E)-cyclobutylmethylidene]-2-methylpropane-2-sulfinamide

(S)-N-[(1R)-1-cyclobutylethyl]-2-methylpropane-2-sulfinamide

cyclobutanemethanol

Downstream raw materials:

(R)-4-((1-cyclobutylethyl)amino)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

(R)-4-((1-cyclobutylethyl)amino)-7-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

(R)-4-((1-cyclobutylethyl)amino)-6-(m-tolyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Refernces

• 1、 Abbott, Jason R.,Patel, Pratiq A.,Howes, Jennifer E.,Akan, Denis T.,Kennedy, J. Phillip,Burns, Michael C.,Browning, Carrie F.,Sun, Qi,Rossanese, Olivia W.,Phan, Jason,Waterson, Alex G.,Fesik, Stephen W.. "Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS". . p. 941 - 946. Retrieved 2018/09/06.
• 2、 -. "SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS". . . Retrieved 2014/07/08.