Imidazo[1,2-a]pyridin-3-ylacetic acid

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-3-ylacetic acid
• CAS No.: 17745-04-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80170311
• Nikkaji Number: J40.938C
• Wikidata: Q27461384
• Mol file: 17745-04-9.mol

Synonyms:17745-04-9;2-(imidazo[1,2-a]pyridin-3-yl)acetic acid;imidazo[1,2-a]pyridin-3-ylacetic acid;Imidazo[1,2-a]pyridine-3-acetic acid;imidazo[1,2-a]pyridin-3-yl-acetic acid;2-imidazo[1,2-a]pyridin-3-ylacetic acid;Imidazo(1,2-a)pyridine-3-acetic acid;BRN 0779907;(3-Imidazo(1,2-a)pyridine)acetic acid;MFCD01720477;2-{imidazo[1,2-a]pyridin-3-yl}acetic acid;SCHEMBL909196;DTXSID80170311;BCP10269;Imidazo(1,2-a)pyridine-3-aceticacid;AKOS005264354;FS-5271;SB34316;AC-25770;Imidazo[1,2-a]pyridin-3-yl acetic acid;LS-80204;SY128989;BB 0259902;CS-0037764;FT-0678433;F30060;A855339;Q27461384;IDL

Chemical Property of Imidazo[1,2-a]pyridin-3-ylacetic acid

Chemical Property:

• Melting Point: 255-256 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.65
• PKA: 2.96±0.10(Predicted)
• PSA: 54.60000
• Density: 1.35 g/cm³
• LogP: 0.96140
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 176.058577502
• Heavy Atom Count: 13
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

2-(Imidazo[1,2-a]pyridin-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=C(N2C=C1)CC(=O)O
• Recent ClinicalTrials: Effects of 2% IDL Lotion on Skin Hydration and Transepidermal Water Loss in Females With Dry Skin
• Uses: 2-(Imidazo[1,2-a]pyridin-3-yl)acetic Acid has been used as a reactant for the preparation of aza-heteroarylbisphosphonate derivatives.

Technology Process of Imidazo[1,2-a]pyridin-3-ylacetic acid

There total 13 articles about Imidazo[1,2-a]pyridin-3-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(imidazo-[1,2-a]pyridin-3-yl)acetamide (21801-86-5) → imidazo<1,2-a>pyridin-3-acetic acid (17745-04-9)

Guidance literature:

With hydrogenchloride; water; In methanol; for 10h; Time; Reflux;

Reference yield: 93.5%

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester (101820-69-3) → imidazo<1,2-a>pyridin-3-acetic acid (17745-04-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 40 - 50 ℃;

Reference yield: 90.0%

2-(imidazo[1,2-α]pyridin-3-yl)acetic acid methyl ester → imidazo<1,2-a>pyridin-3-acetic acid (17745-04-9)

Guidance literature:

With sodium hydroxide; In water; at 40 ℃; for 1h; Temperature;

upstream raw materials:

2-aminopyridine

ethyl 4-oxo-2-butenoate

2-(imidazo[1,2-a]pyridin-3-yl)acetonitrile

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester

Refernces

• 1、 -. "Preparation method of minodronic acid key intermediate". Paragraph 0045; 0073; 0075-0076; 0078-0079; 0081-0082; 0084. . Retrieved 2021/02/24.
• 2、 -. "CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS". Paragraph 0564. . Retrieved 2019/07/13.