1,2-Bis(4-pyridylcarbonyl)hydrazine

Base Information

• Chemical Name: 1,2-Bis(4-pyridylcarbonyl)hydrazine
• CAS No.: 4329-75-3
• Molecular Formula: C12H10N4O2
• Molecular Weight: 242.237
• Hs Code.: 2933399090
• Mol file: 4329-75-3.mol

Synonyms:N,N-Diisonicotinoylhydrazine;N-isonicotinoylisonicotinohydrazide;Bis[2,3-dichloro-[1-oxo[-5-(2-chlorophenyl)-1,2-dithiol-3-ylidene]-2-ethyl]-4-phenoxyacetic acid] disulfide;4-Pyridinecarboxylic acid, 2- (4-pyridinylcarbonyl)hydrazide;N-(pyridine-4-carbonyl)pyridine-4-carbohydrazide;Hydrazine, 1,2-diisonicotinoyl- (8CI);5Ph-1,2-dithiole di-S analog;N, N-Diisonicotinoylhydrazine;4-Pyridinecarboxylic acid, 2-(4-pyridinylcarbonyl)hydrazide (9CI);2-[4-[(2E)-2-[(1E)-2-[4-(carboxymethoxy)-2,3-dichloro-phenyl]-1-[5-(2-chlorophenyl)dithiol-3-ylidene]-2-oxo-ethyl]disulfanyl-2-[5-(2-chlorophenyl)dithiol-3-ylidene]acetyl]-2,3-dichloro-phenoxy]acetic acid;Hydrazine, 1,2-diisonicotinoyl-;

Chemical Property of 1,2-Bis(4-pyridylcarbonyl)hydrazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 250 °C
• Refractive Index: 1.757
• Boiling Point: 551.5 °C at 760 mmHg
• PKA: 8.92±0.23(Predicted)
• Flash Point: 287.3 °C
• PSA: 83.98000
• Density: 1.313g/cm³
• LogP: 1.33320
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98% ^*data from raw suppliers

1,2-Diisonicotinoylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Diisonicotinoylhydrazine is an iron chelator.

Technology Process of 1,2-Bis(4-pyridylcarbonyl)hydrazine

There total 27 articles about 1,2-Bis(4-pyridylcarbonyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

isoniazid (54-85-3,7640-37-1) + triethyl 1,3,5-triazine-2,4,6-tricarboxylate (898-22-6) → N,N'-bis(isonicotinoyl)hydrazine (4329-75-3) + isonicotinamide (1453-82-3) + 3,5-diethoxycarbonyl-1,2,4-triazole (91173-78-3) + isonicotinoylhydrazide of monoethyloxalate imide (91173-79-4)

Guidance literature:

In ethanol; Product distribution; Mechanism; Heating;

Reference yield: 91.0%

isoniazid (54-85-3,7640-37-1) + 1-(4-Pyridylcarbonyl)benzotriazole (144223-31-4) → N,N'-bis(isonicotinoyl)hydrazine (4329-75-3)

Guidance literature:

With trialkylamine; In tetrahydrofuran; for 1h; Microwave irradiation;

DOI:10.1039/c9ra03380g

Reference yield: 91.0%

isoniazid (54-85-3,7640-37-1) → N-(3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-benzamide (109702-97-8) + N,N'-bis(isonicotinoyl)hydrazine (4329-75-3)

Guidance literature:

With 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one; In 1,4-dioxane; for 2h; Heating;

DOI:10.1039/a803973i

upstream raw materials:

4-(chlorocarbonyl)pyridine

isoniazid

ethanol

(E)-N'-(4-oxopentan-2-ylidene)isonicotinohydrazide

Downstream raw materials:

2,5-bis(4-pyridyl)-1,3,4-thiadiazole

pyridine-4-methanol

2,5-bis(4-pyridyl)-1,3,4-oxadiazole

Refernces

• 1、 Mogilaiah,Anitha,Shiva Kumar,Shiva Prasad. "A convenient and simple transformation of acid hydrazides to N,N′-diacylhydrazines with Hg(OAc)2 under solid state conditions". experimental part. p. 126 - 128. Retrieved 2011/03/21.
• 2、 Mogilaiah,Prashanthi,Reddy, G. Randheer. "An Efficient Oxidation of Acid Hydrazides to N,N′-Diacylhydrazines Using Copper(II) Acetate in Solvent-Free Conditions Under Microwave Irradiation". . p. 3741 - 3745. Retrieved 2007/10/03.