2-cyclohexyl-2-hydroxyacetamide

Base Information

• Chemical Name: 2-cyclohexyl-2-hydroxyacetamide
• CAS No.: 4442-93-7
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• Mol file: 4442-93-7.mol

Synonyms:Cyclohexaneglycolamide(6CI,8CI); Glycolamide, 2-cyclohexyl-; NSC 39211

Chemical Property of 2-cyclohexyl-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 9.88E-06mmHg at 25°C
• Boiling Point: 333.2°Cat760mmHg
• Flash Point: 155.3°C
• Density: 1.12g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclohexyl-2-hydroxyacetamide

There total 8 articles about 2-cyclohexyl-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-cyclohexyl-2-hydroxyacetonitrile (100007-62-3,107485-34-7,4354-47-6) → 2-cyclohexyl-2-hydroxyethanamide (4442-93-7)

Guidance literature:

With silver trifluoromethanesulfonate; C₃₃H₃₃ClO₇P₃Pt⁽¹⁺⁾*CF₃O₃S^(1-); In tetrahydrofuran; water; at 40 ℃; Catalytic behavior;

DOI:10.1021/acscatal.1c02254

Reference yield:

2-Chloro-1-cyclohexyl-2-(toluene-4-sulfinyl)-propan-1-ol (134970-67-5) → 2-cyclohexyl-2-hydroxyethanamide (4442-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / xylene / Heating

2: 1) ozone, 2) Me₂S, 29percent aq. ammonia / 1) CH₂Cl₂, -60 deg C, 2) to room temperature

With ammonium hydroxide; dimethylsulfide; ozone; In xylene;

DOI:10.1021/jo00013a011

Reference yield:

→ 2-cyclohexyl-2-hydroxyethanamide (4442-93-7)

Guidance literature:

With ammonia; at 20 ℃; -amide; im Rohr;

upstream raw materials:

(RS)-mandelamide

2-chloro-1-cyclohexyl-2-propen-1-ol

potassium cyanide

2-Chloro-1-cyclohexyl-2-(toluene-4-sulfinyl)-propan-1-ol

Downstream raw materials:

N-[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-2-cyclohexyl-2-hydroxyacetamide

5-cyclohexyl-3-methyl-oxazolidine-2,4-dione

5-cyclohexyl-oxazolidine-2,4-dione

1-amino-2-cyclohexylethan-2-ol

Refernces

• 1、 Satoh, Tsuyoshi,Onda, Ken-ichi,Yamakawa, Koji. "1-Chloroalkyl p-Tolyl Sulfoxides as Useful Agents for Homologation of Carbonyl Compounds: Conversion of Carbonyl Compounds to α-Hydroxy Acids, Esters, and Amides and α,α'-Dihydroxy Ketones". . p. 4129 - 4134. Retrieved 2007/10/02.