Technology Process of N6-(o-Hydroxybenzyl)adenosine-d4
There total 7 articles about N6-(o-Hydroxybenzyl)adenosine-d4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
deuteriated sodium hydroxide; deuterium;
Pd-BaSO4;
at 80 - 85 ℃;
for 5h;
under 1368 Torr;
DOI:10.1271/bbb1961.44.1057
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88.6 percent / K2CO3 / acetone / 2 h / Heating
2: LiAlD4 / diethyl ether / 5 h / Heating
3: H2 / 10percent Pd/C / ethanol / 2 h
4: Et3N / ethanol / 2 h / 80 °C
5: NH3 / methanol / 0 °C
6: 52 percent / D2, 0.3 N NaOD / 5percent Pd/BaSO4 / 5 h / 80 - 85 °C / 1368 Torr
With
lithium aluminium deuteride; deuteriated sodium hydroxide; ammonia; hydrogen; potassium carbonate; triethylamine; deuterium;
palladium on activated charcoal; Pd-BaSO4;
In
methanol; diethyl ether; ethanol; acetone;
DOI:10.1271/bbb1961.44.1057
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Et3N / ethanol / 2 h / 80 °C
2: NH3 / methanol / 0 °C
3: 52 percent / D2, 0.3 N NaOD / 5percent Pd/BaSO4 / 5 h / 80 - 85 °C / 1368 Torr
With
deuteriated sodium hydroxide; ammonia; triethylamine; deuterium;
Pd-BaSO4;
In
methanol; ethanol;
DOI:10.1271/bbb1961.44.1057
