2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE

Base Information

• Chemical Name: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE
• CAS No.: 216502-06-6
• Molecular Formula: C₁₃H₁₁FN₂O
• Molecular Weight: 230.242
• Hs Code.: 2924297099
• Mol file: 216502-06-6.mol

Synonyms:2-amino-N-(4'-fluorophenyl)benzamide

Chemical Property of 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE

Chemical Property:

• Boiling Point: 307.8±27.0 °C(Predicted)
• PKA: 12.22±0.70(Predicted)
• Density: 1.317±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-(4-fluorophenyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE

There total 10 articles about 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

isatoic anhydride (118-48-9) + 4-fluoroaniline (371-40-4) → 2-amino-N-(4'-fluorophenyl)benzamide (216502-06-6)

Guidance literature:

With aqueous extract of mesocarp of fruit of Balanites roxburghii plant; at 60 ℃; for 0.166667h;

DOI:10.1039/c4ra09514f

Reference yield: 81.0%

N-(4-fluorophenyl)-2-nitrobenzamide (135066-26-1) → 2-amino-N-(4'-fluorophenyl)benzamide (216502-06-6)

Guidance literature:

With sodium tetrahydroborate; nickel diacetate; In tetrahydrofuran; methanol;

DOI:10.1021/jm990327e

Reference yield:

4-fluoroaniline (371-40-4) + 2-aminobenzoyl chloride (21563-73-5) → 2-amino-N-(4'-fluorophenyl)benzamide (216502-06-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2018.12.025

upstream raw materials:

isatoic anhydride

4-fluoroaniline

N-(4-fluorophenyl)-2-nitrobenzamide

2-nitrobenzyl chloride

Downstream raw materials:

3-(4-fluorophenyl)quinazolin-4-(3H)-one

4'-Fluoro-2-[(ethoxycarbonyl)amino]benzanilide

3-(4-Fluorophenyl)quinazoline-2,4(1H,3H)-dione

para fluoro benzyl-3 tetrahydro-1,2,3,4 quinazoline

Refernces

• 1、 Ansari, Samira,Asgari, Mohammad Sadegh,Biglar, Mahmood,Esfahani, Ensieh Nasli,Hamedifar, Haleh,Larijani, Bagher,Mahdavi, Mohammad,Mohammadi-Khanaposhtani, Maryam,Rastegar, Hossein,Tas, Recep,Taslimi, Parham. "Design, synthesis, in vitro and in silico biological assays of new quinazolinone-2-thio-metronidazole derivatives". . . Retrieved 2021/07/08.
• 2、 Hou, Taiping,Jiang, Mingfang,Jin, Hong,Tao, Ke,Wan, Jun,Yang, Jian,Zhao, Yongtian. "Synthesis and biological evaluation of novel benodanil-heterocyclic carboxamide hybrids as a potential succinate dehydrogenase inhibitors". . . Retrieved 2020/10/02.