Technology Process of 4-(cyclohepta-2,4,6-trien-1-yl)benzoic acid 6-(4-cyclohepta-1,3,6-trien-1-yl-phenoxy)hexyl ester
There total 4 articles about 4-(cyclohepta-2,4,6-trien-1-yl)benzoic acid 6-(4-cyclohepta-1,3,6-trien-1-yl-phenoxy)hexyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-(4-hydroxyphenyl)-1,3,5-cycloheptatriene;
With
sodium hydride;
In
N,N-dimethyl-formamide; paraffin oil;
at 50 ℃;
Inert atmosphere;
4-(cyclohepta-2,4,6-trien-1-yl)benzoic acid-6-bromo-hexyl ester;
In
N,N-dimethyl-formamide; paraffin oil;
at 50 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -75 °C
1.2: 20 h / -75 - 20 °C
2.1: thionyl chloride / tetrahydrofuran / 4 h / 85 °C
3.1: pyridine / 20 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 50 °C / Inert atmosphere
4.2: 4 h / 50 °C / Inert atmosphere
With
pyridine; n-butyllithium; thionyl chloride; sodium hydride;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; paraffin oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / tetrahydrofuran / 4 h / 85 °C
2.1: pyridine / 20 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 50 °C / Inert atmosphere
3.2: 4 h / 50 °C / Inert atmosphere
With
pyridine; thionyl chloride; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; paraffin oil;