Technology Process of 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester
There total 8 articles about 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pyridine / 2.5 h / Heating
2: 0.79 mol / HCl / reflux, 3 h; RT, overnight
3: 72.9 percent / benzenesulfonic acid / 3 h / Heating
4: 73.8 percent / benzenesulfonic acid / various solvent(s) / 10 h / 168 °C
5: 82 percent / benzenesulfonic acid / dioxane / 1 h / Ambient temperature
6: 95 percent / pyridine / 1.33 h / Ambient temperature
7: 2.) H2O / 1.) pyridine, acetonitrile, 20 deg C, 110 min, 2.) 30 min
8: 2.) 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 1.) pyridine, 2.) pyridine, RT, 65 min
With
hydrogenchloride; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid;
In
1,4-dioxane; pyridine;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72.9 percent / benzenesulfonic acid / 3 h / Heating
2: 73.8 percent / benzenesulfonic acid / various solvent(s) / 10 h / 168 °C
3: 82 percent / benzenesulfonic acid / dioxane / 1 h / Ambient temperature
4: 95 percent / pyridine / 1.33 h / Ambient temperature
5: 2.) H2O / 1.) pyridine, acetonitrile, 20 deg C, 110 min, 2.) 30 min
6: 2.) 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 1.) pyridine, 2.) pyridine, RT, 65 min
With
water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid;
In
1,4-dioxane; pyridine;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 73.8 percent / benzenesulfonic acid / various solvent(s) / 10 h / 168 °C
2: 82 percent / benzenesulfonic acid / dioxane / 1 h / Ambient temperature
3: 95 percent / pyridine / 1.33 h / Ambient temperature
4: 2.) H2O / 1.) pyridine, acetonitrile, 20 deg C, 110 min, 2.) 30 min
5: 2.) 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 1.) pyridine, 2.) pyridine, RT, 65 min
With
water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid;
In
1,4-dioxane; pyridine;