3-(4-fluorophenyl)-3-methylbutyraldehyde

Base Information

• Chemical Name: 3-(4-fluorophenyl)-3-methylbutyraldehyde
• CAS No.: 707-64-2
• Molecular Formula: C₁₁H₁₃FO
• Molecular Weight: 180.222
• Mol file: 707-64-2.mol

Synonyms:3-(4-fluorophenyl)-3-methylbutyraldehyde

Chemical Property of 3-(4-fluorophenyl)-3-methylbutyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-(4-fluorophenyl)-3-methylbutyraldehyde

There total 9 articles about 3-(4-fluorophenyl)-3-methylbutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-fluorophenyl)-3-methylbutan-1-ol (849354-22-9) → 3-(4-fluorophenyl)-3-methylbutyraldehyde (707-64-2)

Guidance literature:

3-(4-fluorophenyl)-3-methylbutan-1-ol; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; for 0.416667h; Cooling with acetone-dry ice;

With triethylamine;

Reference yield:

3,3-dimethyl acrylaldehyde (107-86-8) + ammonium chloride + 4-flourophenylmagnesium bromide (352-13-6) → 3-(4-fluorophenyl)-3-methylbutyraldehyde (707-64-2)

Guidance literature:

copper(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; Petroleum ether;

Reference yield:

4-tert-butylnitrobenzene (3282-56-2) → 3-(4-fluorophenyl)-3-methylbutyraldehyde (707-64-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Raney-Ni

2: (i) aq. HCl, (ii) NaNO₂, aq. HBF₄, (iii) (thermolysis)

3: SO₂Cl₂, (PhCO)2O₂

4: (i) Mg, (ii) /BRN= 605384/

With sulfuryl dichloride; hydrogen; dibenzoyl peroxide; nickel;

upstream raw materials:

β-(4-Fluor-phenyl)-isobutylchlorid

orthoformic acid triethyl ester

4-tert-butylnitrobenzene

4-tert-butylbenzamide

Downstream raw materials:

2-fluoro-5-(4-fluorophenyl)-5-methylhex-1-en-3-ol

Refernces

• 1、 -. "5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides". . . Retrieved 2008/06/13.