Sodium fusidate

Base Information

• Chemical Name: Sodium fusidate
• CAS No.: 751-94-0
• Molecular Formula: C31H47NaO6
• Molecular Weight: 538.70
• Hs Code.: 29419000
• Mol file: 751-94-0.mol

Synonyms:16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid sodium salt;

Chemical Property of Sodium fusidate

Chemical Property:

• Appearance/Colour: while crystalline power
• Vapor Pressure: 7.93E-19mmHg at 25°C
• Boiling Point: 635.6 °C at 760 mmHg
• Flash Point: 197.6 °C
• PSA: 106.89000
• LogP: 4.33140
• Storage Temp.: 2-8°C
• Sensitive.: Moisture & Light Sensitive
• Solubility.: H2O: soluble
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Fusidic Acid Sodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 μg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 μg/ml for all). Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 μM, respectively). Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.
• Uses: Antibacterial;Protein synthesis inhibitor GTPase coupled Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steriodal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells. Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steroidal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells.
• Clinical Use: Antibacterial agent
• Drug interactions: Potentially hazardous interactions with other drugs Antivirals: concentration of both drugs increased in combination with ritonavir and saquinavir - avoid with ritonavir. Statins: increased risk of myopathy with simvastatin and atorvastatin especially in diabetics. Avoid with simvastatin and for 7 days after last dose.1