4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate

Base Information

• Chemical Name: 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate
• CAS No.: 1207746-32-4
• Molecular Formula: C₂HF₃O₂*C₂₀H₁₉ClFN₃O₃S₂
• Molecular Weight: 581.997
• Mol file: 1207746-32-4.mol

Synonyms:4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate

Chemical Property of 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate

There total 2 articles about 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]-1-(methylsulfonyl)piperidine (1207747-35-0) + 2-mercapto-5-chloro-pyridine (40771-41-3) → 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate (1207746-32-4)

Guidance literature:

4-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]-1-(methylsulfonyl)piperidine; In dichloromethane; at 20 ℃; for 16h;

2-mercapto-5-chloro-pyridine; With potassium carbonate; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In 1,2-dimethoxyethane; at 90 ℃; for 2h;

Reference yield:

2-mercapto-5-chloro-pyridine (40771-41-3) + C15H16BrFN2O3S (1262656-86-9) + trifluoroacetic acid (76-05-1) → 4-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}-1-(methylsulfonyl)piperidinium trifluoroacetate (1207746-32-4)

Guidance literature:

2-mercapto-5-chloro-pyridine; With potassium carbonate; In 1,2-dimethoxyethane; at 20 ℃; for 0.25h;

C₁₅H₁₆BrFN₂O₃S; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In 1,2-dimethoxyethane; at 90 ℃; for 2h;

trifluoroacetic acid;

upstream raw materials:

4-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]-1-(methylsulfonyl)piperidine

2-mercapto-5-chloro-pyridine

C₁₅H₁₆BrFN₂O₃S

trifluoroacetic acid

Refernces

• 1、 -. "OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH". Page/Page column 100. . Retrieved 2010/04/03.