2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid

Base Information

• Chemical Name: 2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid
• CAS No.: 1034-10-2
• Molecular Formula: C15H15NO4
• Molecular Weight: 273.288
• European Community (EC) Number: 213-854-6
• DSSTox Substance ID: DTXSID40862705
• Nikkaji Number: J12.262I
• ChEMBL ID: CHEMBL4870852
• Mol file: 1034-10-2.mol

Synonyms:DL-THYRONINE;1034-10-2;2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid;2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid;O-(4-Hydroxyphenyl)-DL-tyrosine;H-4-(4-Hydroxyphenoxy)-DL-Phe-OH;101-66-6;L-Tyrosine, O-(4-hydroxyphenyl)-;EINECS 213-854-6;H-4-(4-Hydroxyphenoxy)-Phe-OH;thyronin;DL-Thyronine, powder;MLS000028627;SCHEMBL285216;2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoicacid;CHEMBL4870852;CHEBI:30661;DTXSID40862705;HMS2231I16;HMS3369G11;DL-Tyrosine, O-(4-hydroxyphenyl)-;MFCD00045864;TERAZOSINHYDROCHLORIDEDIHYDRATE;AKOS016010450;NCGC00018260-02;AS-69056;SMR000058655;CS-0201666;FT-0633257;FT-0701138;T0241;D95358

Chemical Property of 2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid

Chemical Property:

• Vapor Pressure: 6.21E-10mmHg at 25°C
• Refractive Index: 1.633
• Boiling Point: 477.7 °C at 760 mmHg
• PKA: 2.23±0.10(Predicted)
• Flash Point: 242.7 °C
• PSA: 92.78000
• Density: 1.323 g/cm³
• LogP: 2.83920
• Storage Temp.: -15°C
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 273.10010796
• Heavy Atom Count: 20
• Complexity: 307

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dl-Thyronine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC=C(C=C2)O
• Uses: DL-Thyronine can be useful in the study of structure-specific effects of thyroxine analogs on human liver 3α-hydroxysteroid dehydrogenase.

Technology Process of 2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid

There total 8 articles about 2-Amino-3-(4-(4-hydroxyphenoxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ DL-thyronine (1034-10-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01119a027

Reference yield:

3,5-diiodo-DL-thyronine (534-51-0) → DL-thyronine (1034-10-2)

Guidance literature:

With sodium hydroxide; palladium; Hydrogenation;

DOI:10.1577/1548-8659(2000)129<0194:GPSAOO>2.0.CO;2

Reference yield:

→ DL-thyronine (1034-10-2)

Guidance literature:

With phosphorus; hydrogen iodide;

DOI:10.1557/JMR.2000.0014

upstream raw materials:

3,5-diiodo-DL-thyronine

acetic anhydride

Downstream raw materials:

D-thyronine

O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine

ammonia

oxalic acid

Refernces