meclocycline

Base Information

• Chemical Name: meclocycline
• CAS No.: 2013-58-3
• Molecular Formula: C₂₂H₂₁ClN₂O₈
• Molecular Weight: 476.87
• Mol file: 2013-58-3.mol

Synonyms:2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-(6CI,7CI,8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,[4S-(4a,4aa,5a,5aa,12aa)]-; 7-Chloro-6-methylene-5-oxytetracycline; GS 2989;Meclocycline; NSC 78502

Chemical Property of meclocycline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 716.4°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 387.1°C
• PSA: 181.62000
• Density: 1.72g/cm³
• LogP: 0.91580
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Meclocycline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocyline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Meclocycline has been extensively cited in the literature with over 400 references. Meclocycline is a close structural analogue of methacycline which shows antibacterial and antiprotozoan activity.

Technology Process of meclocycline

There total 2 articles about meclocycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-Chlor-6-methylen-5-hydroxy-tetracyclin (2013-58-3,92520-41-7)

Guidance literature:

11a-Chlor-6-methylen-5-hydroxy-tetracyclin 1) N-Chlorsuccinimid, fl. HF 2) Natriumhydrosulfit;

DOI:10.1021/ja01473a043

Reference yield:

→ 7-Chlor-6-methylen-5-hydroxy-tetracyclin (2013-58-3,92520-41-7)

Guidance literature:

7.11a-Dichlor-6-methylen-5-hydroxy-tetracyclin-hydroiodid*2(CH3)2CHOH, methanol. wss. NaHSO3;

DOI:10.1021/ja00907a010