Streptoniazid

Base Information

• Chemical Name: Streptoniazid
• CAS No.: 4480-58-4
• Molecular Formula: C27H44N10O12
• Molecular Weight: 700.71
• NSC Number: 77675
• NCI Thesaurus Code: C152437,C152438
• ChEMBL ID: CHEMBL3091869
• Mol file: 4480-58-4.mol

Synonyms:Streptoniazid;Streptohydrazid;Streptotubazid;Strazide;Streptonicozid base;Streptonicozid (free base);N-[(Z)-[5-[2,4-bis(diaminomethylideneamino)-3,5,6-trihydroxycyclohexyl]oxy-4-[4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-3-hydroxy-2-methyloxolan-3-yl]methylideneamino]pyridine-4-carboxamide;Streptohydrazide;4480-58-4;Streptomycin, isonicotinoylhydrazone;Streptomyclideneisonicotinylhydrazine;Streptonicozid;Streptoniazide [INN-French];Streptoniazidum [INN-Latin];Estreptoniazida [INN-Spanish];C27H44N10O12;NSC 77675;NSC-77675;BRN 0077529;C27-H44-N10-O12;Isonicotinic acid, hydrazide, hydrazone with Streptomycin;CHEMBL3091869;4-Pyridinecarboxylic acid, hydrazide, hydrazone with O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-D-streptamine;NSC77675;Isonicotinic acid, hydrazone with Streptomycin;4-Pyridinecarboxylic acid, hydrazone with O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-D-streptamine

Chemical Property of Streptoniazid

Chemical Property:

• PSA: 368.71000
• Density: 1.86g/cm³
• LogP: -3.96620
• XLogP3: -7.1
• Hydrogen Bond Donor Count: 13
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 11
• Exact Mass: 700.31401688
• Heavy Atom Count: 49
• Complexity: 1210

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=NNC(=O)C4=CC=NC=C4)O
• Isomeric SMILES: CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(/C=N\NC(=O)C4=CC=NC=C4)O

Technology Process of Streptoniazid

There total 1 articles about Streptoniazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) + streptomicin (57-92-1) → streptomycin-isonicotinoylhydrazone (4480-58-4)

Guidance literature:

With water; pH 7.0-7.2;

DOI:10.1021/ja01104a046

Reference yield:

streptomycin-isonicotinoylhydrazone (4480-58-4) → (1R)-N,N'-dicarbamimidoyl-O4-{3-[(N'-isonicotinoyl-hydrazino)-methyl]-O2-(2-methylamino-2-deoxy-α-L-glucopyranosyl)-5-deoxy-α-L-lyxofuranosyl}-streptamine (121621-53-2)

Guidance literature:

With water; platinum; at 40 - 75 ℃; under 735.5 - 58840.6 Torr; Hydrogenation;

upstream raw materials:

isoniazid

streptomicin

Downstream raw materials:

(1R)-N,N'-dicarbamimidoyl-O⁴-{3-[(N'-isonicotinoyl-hydrazino)-methyl]-O²-(2-methylamino-2-deoxy-α-L-glucopyranosyl)-5-deoxy-α-L-lyxofuranosyl}-streptamine