Technology Process of Piv-Ach-L-Ser(OBn)-NHMe
There total 7 articles about Piv-Ach-L-Ser(OBn)-NHMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
for 16h;
DOI:10.1021/jo016406r
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 204 mg / Et3N / CH2Cl2 / 24 h / 0 - 20 °C
2: 100 percent / H2 / Pd/C / methanol / 2 h / 20 °C
3: 63 percent / diisopropylethylamine; TBTU / acetonitrile / 16 h / 20 °C
With
hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo016406r
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. HCl / tetrahydrofuran / 16 h / 20 °C
2: 204 mg / Et3N / CH2Cl2 / 24 h / 0 - 20 °C
3: 100 percent / H2 / Pd/C / methanol / 2 h / 20 °C
4: 63 percent / diisopropylethylamine; TBTU / acetonitrile / 16 h / 20 °C
With
hydrogenchloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo016406r
