meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane

Base Information

• Chemical Name: meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane
• CAS No.: 85720-53-2
• Molecular Formula: C₂₀H₂₄Cl₂O₂
• Molecular Weight: 367.315
• Mol file: 85720-53-2.mol

Synonyms:meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane

Chemical Property of meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane

There total 2 articles about meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

1-(2-chloro-4-methoxyphenyl)-1-propanol (85720-54-3) → meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane (85720-53-2)

Guidance literature:

With lithium aluminium tetrahydride; titanium(III) chloride; In 1,2-dimethoxyethane; for 16h; Heating;

DOI:10.1021/jm00362a010

Reference yield:

1-(2-chloro-4-methoxylphenyl)propan-1-one (13329-61-8) → meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane (85720-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / LiAlH₄ / diethyl ether / 1.) RT, 3 h, 2.) reflux, 1 h

2: 18 percent / TiCl₃, LiAlH₄ / 1,2-dimethoxy-ethane / 16 h / Heating

With lithium aluminium tetrahydride; titanium(III) chloride; In 1,2-dimethoxyethane; diethyl ether;

DOI:10.1021/jm00362a010

Reference yield: 83.0%

meso-3,4-bis(2-chloro-4-methoxyphenyl)hexane (85720-53-2) → C18H20Cl2O2 (95426-60-1)

Guidance literature:

With boron tribromide; In dichloromethane; 1.) -60 deg C, 0.5 h, 2.) RT, 4 h;

DOI:10.1021/jm00362a010

upstream raw materials:

1-(2-chloro-4-methoxyphenyl)-1-propanol

1-(2-chloro-4-methoxylphenyl)propan-1-one

Downstream raw materials:

C₁₈H₂₀Cl₂O₂

Refernces