Technology Process of 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
There total 11 articles about 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 18 h / 20 °C / Cooling with ice
2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
With
carbon tetrabromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere
2: potassium carbonate / acetonitrile / 18 h / 20 °C
3: potassium hydroxide / dimethyl sulfoxide / 18 h / 95 °C
4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
7: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
With
boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;