mercaptopropionylhydrazide

Base Information

• Chemical Name: mercaptopropionylhydrazide
• CAS No.: 689-02-1
• Molecular Formula: C3H8 N2 O S
• Molecular Weight: 120.17
• Hs Code.: 2930909090
• Mol file: 689-02-1.mol

Synonyms:Propionicacid, 3-mercapto-, hydrazide (6CI,7CI,8CI); 3-Mercaptopropionic acid hydrazide;3-Mercaptopropionyl hydrazide; b-Mercaptopropionic acid hydrazide

Chemical Property of mercaptopropionylhydrazide

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Boiling Point: 337.7°C at 760 mmHg
• Flash Point: 158°C
• PSA: 97.41000
• Density: 1.181g/cm³
• LogP: 0.83680

Purity/Quality:

99%, ^*data from raw suppliers

3-sulfanylpropanehydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mercaptopropionylhydrazide

There total 2 articles about mercaptopropionylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Methyl 3-mercaptopropionate (2935-90-2) → 3-mercaptopropionic acid hydrazide (689-02-1)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃;

DOI:10.1039/c0ob00214c

Reference yield:

3-mercaptopropionic acid ethyl ester (5466-06-8) → 3-mercaptopropionic acid hydrazide (689-02-1)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jm00325a007

Reference yield: 81.0%

3-mercaptopropionic acid hydrazide (689-02-1) + C19H16O3S (1219077-43-6) → (E)-S-3-((3-ethynyl-5-((2-(3-mercaptopropanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate (1256478-10-0)

Guidance literature:

With acetic acid; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja106486b

upstream raw materials:

3-mercaptopropionic acid ethyl ester

Methyl 3-mercaptopropionate

Downstream raw materials:

3-Mercapto-propionic acid [1-(2,6-dichloro-phenyl)-meth-(E)-ylidene]-hydrazide

1-(5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-3-sulfanylpropane-1-one

2-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3,4-thiadiazepin-5-one

N'-(4-methylbenzylidene)-3-sulfanylpropionohydrazide

Refernces

• 1、 Tan, Ronghua,Tian, Danlei,Liu, Jiaoyan,Wang, Congcong,Wan, Ying. "Doxorubicin-bound hydroxyethyl starch conjugate nanoparticles with pH/redox responsive linkage for enhancing antitumor therapy". . p. 4527 - 4544. Retrieved 2021/07/28.
• 2、 Von Delius, Max,Geertsema, Edzard M.,Leigh, David A.,Slawin, Alexandra M. Z.. "Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions". experimental part. p. 4617 - 4624. Retrieved 2010/11/19.