(Z)-ethyl 2-oxo-4-phenyl-3-butenoate

Base Information

• Chemical Name: (Z)-ethyl 2-oxo-4-phenyl-3-butenoate
• CAS No.: 55674-14-1
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.225
• Mol file: 55674-14-1.mol

Synonyms:(Z)-ethyl 2-oxo-4-phenyl-3-butenoate

Chemical Property of (Z)-ethyl 2-oxo-4-phenyl-3-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-ethyl 2-oxo-4-phenyl-3-butenoate

There total 43 articles about (Z)-ethyl 2-oxo-4-phenyl-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-oxo-5-phenylpent-4-enoate (1503-99-7,58369-48-5) → ethyl 4-phenyl-2-oxobut-3-enoate (55629-96-4,55674-14-1,17451-20-6)

Guidance literature:

With aluminum (III) chloride; Oxone; In water; at 20 ℃; for 4h;

DOI:10.1021/jo4009047

Reference yield: 94.0%

ethanol (64-17-5) + benzylidene pyruvic acid (17451-19-3) → ethyl 4-phenyl-2-oxobut-3-enoate (55629-96-4,55674-14-1,17451-20-6)

Guidance literature:

With sulfuric acid; at 40 ℃; Temperature;

Reference yield: 92.0%

2-Oxo-4-phenyl-3-phenylselanyl-butyric acid ethyl ester (200286-34-6) → (E)-ethyl-2-oxo-4-phenylbut-3-enoate (17451-20-6,55674-14-1,55629-96-4)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; In ethanol; water; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(97)10117-X

upstream raw materials:

ethanol

benzylidene pyruvic acid

ethyl iodide

glyoxylic acid ethyl ester

Downstream raw materials:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

(S)-ethyl 2-hydroxy-4-phenylbutyrate

(2S)-(E)-2-Hydroxy-4-phenylbut-3-enoic acid ethyl ester

(4R)-ethyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

Refernces

• 1、 Roscales, Silvia,Csáky, Aurelio G.. "Synthesis of Ketones by C?H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions". supporting information. p. 8728 - 8732. Retrieved 2021/03/16.
• 2、 Pommidi, Anil,Shaik, Asha Begum,Chatterjee, Anindita,Somarapu, Vijaya Laxmi. "Iodine mediated a simple strategy for the synthesis of β,γ-unsaturated-α-ketoesters and its application for the synthesis of 4,5-dihydropyrazole derivatives". . p. 1545 - 1553. Retrieved 2020/03/05.