3-Amino-2-methylphenol

Base Information

• Chemical Name: 3-Amino-2-methylphenol
• CAS No.: 53222-92-7
• Molecular Formula: C7H9 N O
• Molecular Weight: 123.155
• Hs Code.: 2922299090
• European Community (EC) Number: 258-438-5
• DSSTox Substance ID: DTXSID50201323
• Nikkaji Number: J236.335F
• Wikidata: Q72439848
• Mol file: 53222-92-7.mol

Synonyms:3-Amino-2-methylphenol;53222-92-7;3-Amino-o-cresol;Phenol, 3-amino-2-methyl-;2-Amino-o-cresol;3-Hydroxy-2-methylaniline;2-Methyl-3-aminophenol;EINECS 258-438-5;MFCD00007787;3-amino-2-methyl-phenol;aminokresol;o-Cresol, 3-amino-;2-methyl-3-amino-phenol;3-amino-2-methyl phenol;3A2MP;2-Methyl-3-Hydroxy Aniline;SCHEMBL71383;BIDD:GT0134;3-Amino-2-methylphenol, 95%;DTXSID50201323;BCP18857;AKOS009157938;CS-W004418;AS-31335;SY002452;AM20080677;FT-0640141;A829458;J-511552

Chemical Property of 3-Amino-2-methylphenol

Chemical Property:

• Vapor Pressure: 0.0217mmHg at 25°C
• Melting Point: 127-133 ºC
• Refractive Index: 1.5380 (estimate)
• Boiling Point: 267.1°Cat760mmHg
• PKA: 10.36±0.10(Predicted)
• Flash Point: 115.4°C
• PSA: 46.25000
• Density: 1.157g/cm³
• LogP: 1.86400
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 94.9

Purity/Quality:

98% ^*data from raw suppliers

3-Amino-2-methylphenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C=CC=C1O)N
• Uses: 3-Amino-2-methylphenol is used in production of (Diimido)dicarboxylic Acid, Imide, Polyamic Acid, Polyamides, Polyesters, and Polyureas.

Technology Process of 3-Amino-2-methylphenol

There total 5 articles about 3-Amino-2-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-nitro-o-cresol (5460-31-1) → amino-6 hydroxy-2 toluene (53222-92-7)

Guidance literature:

palladium on charcoal; In ethanol;

Reference yield: 42.0%

o-toluidine (95-53-4) → 3-amino-4-methylphenol (2836-00-2) + amino-6 hydroxy-2 toluene (53222-92-7)

Guidance literature:

With dihydrogen peroxide; antimony pentafluoride; In hydrogen fluoride; at -20 ℃; for 0.25h; Mechanism; Product distribution;

Reference yield:

3-nitro-o-tolylamine (603-83-8) → amino-6 hydroxy-2 toluene (53222-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Diazotization

2: tin; tin dichloride; hydrochloric acid / auf dem Wasserbade

With hydrogenchloride; tin; tin(ll) chloride;

upstream raw materials:

3-nitro-o-cresol

o-toluidine

3-nitro-o-tolylamine

2,6-dinitrotoluene

Downstream raw materials:

4,8-dimethyl-3H-phenoxazin-3-one

2-hydroxy-5-methyl-N-(2'-hydroxy-5'-methylphenyl)benzoquinone monoimine

N-(2'-hydroxy-5'-methylphenyl)-2,8-dimethyl-3H-phenoxazin-3-onimine

2,9-dimethyl-5a,6-dihydro-5a-methyltriphendioxazine

Refernces

• 1、 Salahshournia, Hossein,Ghiaci, Mehran. "Pd-Pt/modified GO as an efficient and selective heterogeneous catalyst for the reduction of nitroaromatic compounds to amino aromatic compounds by the hydrogen source". . . Retrieved 2019/02/14.
• 2、 -. "Diphenyl sulfate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating hepatitis C virus related diseases". Paragraph 0182-0184. . Retrieved 2017/05/23.