5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine

Base Information

• Chemical Name: 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine
• CAS No.: 23470-40-8
• Molecular Formula: C₁₂H₁₈N₄O₂
• Molecular Weight: 250.301
• Mol file: 23470-40-8.mol

Synonyms:5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine

Chemical Property of 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine

Chemical Property:

• Melting Point: 125 °C
• Boiling Point: 452.5±45.0 °C(Predicted)
• Density: 1.224±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine

There total 7 articles about 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-(4-ethyl-1-piperazinyl)-2'-nitroacetanilide (23470-34-0) → 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine (23470-40-8)

Guidance literature:

With sulfuric acid; at 80 ℃;

DOI:10.1021/jm5003028

Reference yield: 92.9%

4-ethylpiperazine (5308-25-8) + 5-chloro-2-nitroaniline (1635-61-6) → 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine (23470-40-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; Inert atmosphere;

Reference yield: 77.0%

4-ethylpiperazine (5308-25-8) + 5-fluoro-2-nitroaniline (2369-11-1) → 5-(4-ethylpiperazin-1-yl)-2-nitrophenylamine (23470-40-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 4h;

DOI:10.1021/acs.jmedchem.6b00056

upstream raw materials:

4-ethylpiperazine

5-chloro-2-nitroaniline

N-(5-chloro-2-nitrophenyl)acetamide

5-(4-ethyl-1-piperazinyl)-2'-nitroacetanilide

Downstream raw materials:

5-(4-ethylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

5-(4-ethylpiperazin-1-yl)-2-[2′-(3,4-dimethoxyphenyl)-5′-benzimidazolyl]benzimidazole

5-(4-ethylpiperazin-1-yl)-2-[2′-(4-ethoxyphenyl)-5′-benzimidazolyl]benzimidazole

4-(4-ethylpiperazin-1-yl)benzene-1,2-diamine

Refernces

• 1、 Yan, Wei,Wang, Xinyi,Dai, Yang,Zhao, Bin,Yang, Xinying,Fan, Jun,Gao, Yinglei,Meng, Fanwang,Wang, Yuming,Luo, Cheng,Ai, Jing,Geng, Meiyu,Duan, Wenhu. "Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation". supporting information. p. 6690 - 6708. Retrieved 2016/08/06.
• 2、 -. "PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES". Page/Page column 32-34. . Retrieved 2014/09/29.