[4-(BROMOMETHYL)BENZYL]TRIPHENYLPHOSPHONIUM BROMIDE

Base Information

• Chemical Name: [4-(BROMOMETHYL)BENZYL]TRIPHENYLPHOSPHONIUM BROMIDE
• CAS No.: 14366-74-6
• Molecular Formula: C26H23Br2P
• Molecular Weight: 526.25
• Hs Code.: 2931900090
• Mol file: 14366-74-6.mol

Synonyms:Phosphonium,[[4-(bromomethyl)phenyl]methyl]triphenyl-, bromide (9CI);Phosphonium, [p-(bromomethyl)benzyl]triphenyl-,bromide (8CI);[p-(Bromomethyl)benzyl]triphenylphosphonium bromide (6CI);NSC 81281;

Chemical Property of [4-(BROMOMETHYL)BENZYL]TRIPHENYLPHOSPHONIUM BROMIDE

Chemical Property:

• Appearance/Colour: almost white powder
• Melting Point: 270-273 °C
• PSA: 13.59000
• LogP: 3.07960

Purity/Quality:

99%, ^*data from raw suppliers

4-(BROMOMETHYL)BENZYLTRIPHENYLPHOSPHONIUM BROMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(BROMOMETHYL)BENZYL]TRIPHENYLPHOSPHONIUM BROMIDE

There total 2 articles about [4-(BROMOMETHYL)BENZYL]TRIPHENYLPHOSPHONIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,4-bis(bromomethyl)benzene (623-24-5) + triphenylphosphine (603-35-0) → (4-(bromomethyl)benzyl)triphenylphosphonium bromide (14366-74-6)

Guidance literature:

In toluene; for 4h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1002/chem.201404107

Reference yield:

→ (4-(bromomethyl)benzyl)triphenylphosphonium bromide (14366-74-6)

Guidance literature:

1,4-Bis-brommethyl-benzol, Triphenylphosphin, DMF;

Reference yield: 91.7%

(4-(bromomethyl)benzyl)triphenylphosphonium bromide (14366-74-6) + trifluoroacetic acid (76-05-1) + tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide → triphenyl(4-((4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)benzyl)phosphonium trifluoroacetate

Guidance literature:

(4-(bromomethyl)benzyl)triphenylphosphonium bromide; tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide; With sodium carbonate; In acetonitrile; for 24h; Inert atmosphere; Schlenk technique; Reflux;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201404107

upstream raw materials:

1,4-bis(bromomethyl)benzene

triphenylphosphine

Downstream raw materials:

(4-(((2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)methyl)benzyl)triphenylphosphonium bromide

(4-(((2-((tert-butoxycarbonyl)amino)ethyl)(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amino)methyl)benzyl)triphenylphosphonium bromide

Refernces

• 1、 Wang, Jianjun,Yang, Chang-Tong,Kim, Young-Seung,Sreerama, Subramanya G.,Cao, Qizhen,Li, Zi-Bo,He, Zhengjie,Chen, Xiaoyuan,Liu, Shuang. "64Cu-labeled triphenylphosphonium and triphenylarsonium cations as highly tumor-selective imaging agents". . p. 5057 - 5069. Retrieved 2007.
• 2、 -. "Hydroxyl benzoquinone biquaternary ammonium salt and preparation and application thereof". Paragraph 0011; 0012. . Retrieved 2020/05/02.
• 3、 Morrison, Daniel E.,Aitken, Jade B.,De Jonge, Martin D.,Issa, Fatiah,Harris, Hugh H.,Rendina, Louis M.. "Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents". supporting information. p. 16602 - 16612. Retrieved 2015/09/29.