2-bromobutyrophenone

Base Information

• Chemical Name: 2-bromobutyrophenone
• CAS No.: 877-35-0
• Molecular Formula: C10H11 Br O
• Molecular Weight: 227.101
• Hs Code.: 2914700090
• Mol file: 877-35-0.mol

Synonyms:Butyrophenone,2-bromo- (6CI,7CI,8CI); Butyrophenone, a-bromo- (4CI); 1-Benzoyl-1-bromopropane;1-Phenyl-2-bromo-1-butanone; 2-Bromo-1-phenyl-1-butanone; 2-Bromobutyrophenone;NSC 115003; a-Bromobutyrophenone

Chemical Property of 2-bromobutyrophenone

Chemical Property:

• Vapor Pressure: 0.00936mmHg at 25°C
• Melting Point: 36 °C
• Boiling Point: 265.1°C at 760 mmHg
• Flash Point: 52.9°C
• PSA: 17.07000
• Density: 1.355g/cm³
• LogP: 3.04280
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

98% ^*data from raw suppliers

α-Bromobutyrophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromobutyrophenone

There total 11 articles about 2-bromobutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

propiophenone (495-40-9) → 2-bromo-1-phenylbutan-1-one (877-35-0,73908-28-8)

Guidance literature:

With bromine; at 20 ℃; for 0.333333h;

DOI:10.1021/jm0211117

Reference yield: 94.0%

1-butylbenzene (104-51-8) → 2-bromo-1-phenylbutan-1-one (877-35-0,73908-28-8)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; In ethyl acetate; at 60 ℃; for 6h;

DOI:10.1002/ejoc.201900100

Reference yield: 79.0%

1-phenyl-1-butyne (622-76-4,83585-27-7) → 2-bromo-1-phenylbutan-1-one (877-35-0,73908-28-8)

Guidance literature:

1-phenyl-1-butyne; With trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; In dichloromethane; at -78 - 0 ℃;

With water; sodium hydroxide; In dichloromethane; at 0 - 40 ℃; for 12h;

With sodium dihydrogenphosphate; potassium bromide; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1039/c9sc00568d

upstream raw materials:

propiophenone

2-bromo-butyryl bromide

benzene

2-bromobutanoyl chloride

Downstream raw materials:

2-(4-chloro-phenoxy)-1-phenyl-butan-1-one

2-phenoxy-1-phenylbutan-1-one

2-hydroxy-1-phenyl-butan-1-one-(methyl-phenyl-acetal)

2-hydroxy-1-phenyl-butan-1-one-diethylacetal

Refernces

• 1、 Sedano, Carlos,Virumbrales, Cintia,Suárez-Pantiga, Samuel,Sanz, Roberto. "Aldol-Tishchenko Reaction of α-Oxy Ketones: Diastereoselective Synthesis of 1,2,3-Triol Derivatives". supporting information. p. 3725 - 3734. Retrieved 2021/07/02.
• 2、 Matsuta, Shuntaro,Shima, Noriaki,Kakehashi, Hidenao,Ishikawa, Akari,Asai, Ryutaro,Nitta, Atsushi,Wada, Misato,Nakano, Shihoko,Kamata, Hiroe,Nishiyama, Yoshio,Nagatani, Hirohisa,Imura, Hisanori,Katagi, Munehiro. "Dehydration-fragmentation mechanism of cathinones and their metabolites in ESI-CID". . . Retrieved 2020/09/11.