2-Amino-3-cyanopyridine

Base Information

• Chemical Name: 2-Amino-3-cyanopyridine
• CAS No.: 24517-64-4
• Molecular Formula: C6H5N3
• Molecular Weight: 119.126
• Hs Code.: 29333990
• European Community (EC) Number: 627-986-0
• DSSTox Substance ID: DTXSID80355929
• Nikkaji Number: J3.165.196D
• Wikidata: Q72435115
• ChEMBL ID: CHEMBL4585655
• Mol file: 24517-64-4.mol

Synonyms:2-amino-3-cyanopyridine;2-aminonicotinonitrile;3-pyridinecarbonitrile, 2-amino-

Chemical Property of 2-Amino-3-cyanopyridine

Chemical Property:

• Appearance/Colour: Off-white cryst.
• Vapor Pressure: 0.00134mmHg at 25°C
• Melting Point: 133-135 °C
• Boiling Point: 297.6 °C at 760 mmHg
• PKA: 3.09±0.36(Predicted)
• Flash Point: 133.8 °C
• PSA: 62.70000
• Density: 1.23 g/cm³
• LogP: 1.11668
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 119.048347172
• Heavy Atom Count: 9
• Complexity: 135

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)N)C#N

Technology Process of 2-Amino-3-cyanopyridine

There total 1 articles about 2-Amino-3-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-amino-3-pyridinecarbonitrile (24517-64-4) + isopropyl benzoate (939-48-0)

Guidance literature:

With Zn⁽²⁺⁾*2C₂H₃O₂^(1-)*17H₂O; at 75 ℃; for 6h;

Reference yield: 93.0%

2-amino-3-pyridinecarbonitrile (24517-64-4) + benzaldehyde (100-52-7) → 2-phenyl-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one (31911-79-2)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 100 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1039/c2gc16469h

Reference yield: 91.0%

2-amino-3-pyridinecarbonitrile (24517-64-4) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → (2-aminopyridin-3-yl)(3,4-dimethoxyphenyl)methanone

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water; In 2-methyltetrahydrofuran; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1039/c4ob00978a

Downstream raw materials:

2-aminopyridin-3-carboxylic acid

2-aminopyridine-3-carboxamide

2-(benzoylamino)-3-cyanopyridine

8-imidazo<1,2-a>pyridinecarbonitrile

Refernces