[2-(Diethylamino)phenyl]methanol

Base Information

• Chemical Name: [2-(Diethylamino)phenyl]methanol
• CAS No.: 87066-93-1
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.262
• European Community (EC) Number: 887-061-4
• Nikkaji Number: J410.109J
• Mol file: 87066-93-1.mol

Synonyms:[2-(diethylamino)phenyl]methanol;87066-93-1;SCHEMBL5317695;AKOS009247973;EN300-53649;Z362021610

Chemical Property of [2-(Diethylamino)phenyl]methanol

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 179.131014166
• Heavy Atom Count: 13
• Complexity: 134

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C1=CC=CC=C1CO

Technology Process of [2-(Diethylamino)phenyl]methanol

There total 5 articles about [2-(Diethylamino)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-(N,N-diethylamino)benzoate (94023-76-4) → (2-Diethylamino-phenyl)-methanol (87066-93-1)

Guidance literature:

With sodium tetrahydroborate; zinc(II) chloride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1246/bcsj.64.2730

Reference yield:

N,N-diethylanthranilic acid methyl ester (91563-72-3) → (2-Diethylamino-phenyl)-methanol (87066-93-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm950610n

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → (2-Diethylamino-phenyl)-methanol (87066-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm950610n

upstream raw materials:

N-acetyl-N-ethyl-anthranilic acid ethyl ester

ethyl 2-(N,N-diethylamino)benzoate

N,N-diethylanthranilic acid methyl ester

methyl 2-fluorobenzoate

Downstream raw materials:

(2-Chloromethyl-phenyl)-diethyl-amine

2-(2-Dibutylamino-phenyl)-thiazolidine-3-carbothioic acid methylamide; compound with sulfuric acid

2-(2-Diethylamino-phenyl)-thiazolidine-3-carbothioic acid methylamide; compound with sulfuric acid

Diethyl-[2-(1-pyridin-2-ylmethyl-1,4,5,6-tetrahydro-cyclopentaimidazol-2-ylsulfanylmethyl)-phenyl]-amine

Refernces

• 1、 Yamakawa, Tomio,Masaki, Mitsuo,Nohira, Hiroyuki. "A New Reduction of Some Carboxylic Esters with Sodium Borohydride and Zinc Chloride in the Presence of a Tertiary Amine". . p. 2730 - 2734. Retrieved 2007/10/02.