N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

Base Information

• Chemical Name: N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide
• CAS No.: 4510-09-2
• Molecular Formula: C₁₃H₁₇N₃O₅
• Molecular Weight: 295.295
• Mol file: 4510-09-2.mol

Synonyms:N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

Chemical Property of N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

There total 7 articles about N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid (35726-62-6,1029401-62-4) → N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide (4510-09-2)

Guidance literature:

With ethanol; hydrazine hydrate; at 20 ℃;

DOI:10.1038/163604b0

Reference yield:

D-glutamic acid-5-methyl ester; hydrochloride (27025-22-5) → N-benzyloxycarbonyl-D-glutamic acid-5-hydrazide (4510-09-2)

Guidance literature:

With water; sodium hydrogencarbonate; anschliessend Behandeln mit Chlorokohlensaeure-benzylester und Erwaermen des Reaktionsprodukts mit N₂H₄+H₂O;

DOI:10.1016/0040-4020(58)88042-4

Reference yield:

(S)-2-Amino-pentanedioic acid 5-ethyl ester (1119-33-1) → N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide (4510-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: MgO / unter Kuehlung

2: hydrazine hydrate / 100 °C

With magnesium oxide; hydrazine hydrate;

DOI:10.1002/hlca.19480310309

upstream raw materials:

(S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid

γ-methyl L-glutamate hydrochloride

Cbz-L-pGlu-OH

L-glutamic acid

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-leucine

N-{(S)-2-[(N-benzyloxycarbonyl-L-γ-glutamyl)-amino]-butyryl}-glycine

N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-glutamic acid dibenzyl ester

N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester

Refernces

• 1、 LE QUESNE,YOUNG. "Synthesis of gamma-glutamyl peptides.". . p. 604 - 604. Retrieved 2007/10/05.