N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide

Base Information

• Chemical Name: N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide
• CAS No.: 23428-48-0
• Molecular Formula: C₃₇H₃₅NO₄
• Molecular Weight: 557.689
• Mol file: 23428-48-0.mol

Synonyms:N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide

Chemical Property of N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide

There total 4 articles about N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(benzyloxy)phenyl]acetonitrile (838-96-0) → N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide (23428-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide, water / ethane-1,2-diol / 18 h / Heating

2: oxalyl chloride, DMF / benzene / 1 h / 20 °C

3: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1.5 h

With potassium hydroxide; oxalyl dichloride; water; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; water; ethylene glycol; benzene;

DOI:10.1039/P19810002016

Reference yield:

3,4-bis(benzyloxy)-β-nitrostyrene (1699-54-3) → N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide (23428-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / lithium aluminium hydride / tetrahydrofuran / 1.25 h / Heating

2: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1.5 h

With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/P19810002016

Reference yield:

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide (23428-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / benzene / 1 h / 20 °C

2: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1.5 h

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; water; benzene;

DOI:10.1039/P19810002016

upstream raw materials:

2-(4-(benzyloxy)phenyl)acetyl chloride

2-(3,4-bis (phenylmethoxy)phenyl)ethylamine hydrochloride

2-[4-(benzyloxy)phenyl]acetonitrile

3,4-bis(benzyloxy)-β-nitrostyrene

Downstream raw materials:

6,7-bisbenzyloxy-1-(4-benzyloxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

6,7-dihydroxy-1-(4-hydroxybenzyl)-3,4-dihydroisoquinoline hydrochloride

N-(4-benzyloxyphenethyl)-N-(3,4-bisbenzyloxyphenethyl)amine

Refernces