ethyl 2-methyl-4,4,4-trifluorobutanoate

Base Information

• Chemical Name: ethyl 2-methyl-4,4,4-trifluorobutanoate
• CAS No.: 143484-00-8
• Molecular Formula: C₇H₁₁F₃O₂
• Molecular Weight: 184.158
• Hs Code.: 2915907098
• Mol file: 143484-00-8.mol

Synonyms:ethyl 2-methyl-4,4,4-trifluorobutanoate

Chemical Property of ethyl 2-methyl-4,4,4-trifluorobutanoate

Chemical Property:

• Boiling Point: 142～145℃
• Density: 1.120±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-methyl-4,4,4-trifluorobutyrate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-methyl-4,4,4-trifluorobutanoate

There total 2 articles about ethyl 2-methyl-4,4,4-trifluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl 4,4,4-trifluorobutanoate (371-26-6) + methyl iodide (74-88-4) → ethyl 2-methyl-4,4,4-trifluorobutanoate (143484-00-8)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

→ ethyl 2-methyl-4,4,4-trifluorobutanoate (143484-00-8)

Guidance literature:

Reference yield: 99.0%

ethyl 2-methyl-4,4,4-trifluorobutanoate (143484-00-8) → 4,4,4-trifluoro-2-methylbutanoic acid (99783-23-0)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water;

upstream raw materials:

ethyl 4,4,4-trifluorobutanoate

methyl iodide

Downstream raw materials:

4,4,4-trifluoro-2-methylbutanoic acid

ethyl 4,4,4-trifluoro-2,2-dimethylbutanoate

4,4,4-trifluoro-2,2-dimethylbutanoic acid

3-Methoxy-4-[1-methyl-5-(4,4,4-trifluoro-2,2-dimethyl-butylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid

Refernces

• 1、 Jacobs, Robert T.,Bernstein, Peter R.,Cronk, Laura A.,Vacek, Edward P.,Newcomb, Lisa F.,et al.. "Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-indolecarboxamides: Identification of 4--1-methylindol-3-yl>methyl>-3-methoxy-N-benzamide, ...". . p. 1282 - 1297. Retrieved 2007/10/02.