Technology Process of p-methoxybenzyl (5R,6S)-6-bromo-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
There total 16 articles about p-methoxybenzyl (5R,6S)-6-bromo-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphorous acid trimethyl ester;
In
toluene;
at 50 ℃;
for 1h;
Yield given;
DOI:10.1039/P19940000179
- Guidance literature:
-
Multi-step reaction with 7 steps
1: m-chloroperbenzoic acid / CH2Cl2 / 1.5 h / 5 °C
2: toluene / Heating
3: toluene / Heating
4: Et3N / toluene / 2 h / 5 °C
5: NaI, 4-N,N-dimethylaminopyridine, PPh3 / acetonitrile / -20 deg C, 30 min then 5 deg C, 45 min
6: O3 / ethyl acetate / 1 h / -78 °C
7: trimethyl phosphite / toluene / 30 h / 95 °C
With
dmap; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium iodide; phosphorous acid trimethyl ester;
In
dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1039/c39890000371
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / Heating
2: toluene / Heating
3: Et3N / toluene / 2 h / 5 °C
4: NaI, 4-N,N-dimethylaminopyridine, PPh3 / acetonitrile / -20 deg C, 30 min then 5 deg C, 45 min
5: O3 / ethyl acetate / 1 h / -78 °C
6: trimethyl phosphite / toluene / 30 h / 95 °C
With
dmap; ozone; triethylamine; triphenylphosphine; sodium iodide; phosphorous acid trimethyl ester;
In
ethyl acetate; toluene; acetonitrile;
DOI:10.1039/c39890000371