5-METHYLPYROGALLOL

Base Information

• Chemical Name: 5-METHYLPYROGALLOL
• CAS No.: 609-25-6
• Molecular Formula: C7H8O3
• Molecular Weight: 140.139
• Hs Code.: 2907299090
• Mol file: 609-25-6.mol

Synonyms:Pyrogallol,5-methyl- (6CI,7CI,8CI);2,6-Dihydroxy-5-methylphenol;5-Methylbenzene-1,2,3-triol;5-Methylpyrogallol;

Chemical Property of 5-METHYLPYROGALLOL

Chemical Property:

• Vapor Pressure: 0.000146mmHg at 25°C
• Melting Point: 125 °C
• Refractive Index: 1.647
• Boiling Point: 322.7 °C at 760 mmHg
• PKA: 9.40±0.15(Predicted)
• Flash Point: 166.5 °C
• PSA: 60.69000
• Density: 1.387 g/cm³
• LogP: 1.11180

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methylpyrogallol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methylpyrogallol has been used in studies such as glyoxalase 1-?inhibition activity, and the mechanism of the xanthine oxidase (XO) inhibitory activity of pyrogallol as it is a compound closely related in structure to pyrogallol.

Technology Process of 5-METHYLPYROGALLOL

There total 21 articles about 5-METHYLPYROGALLOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4,5-trimethoxytoluene (6443-69-2) → 5-methylpyrogallol (609-25-6)

Guidance literature:

With hydrogen iodide; hypophosphorous acid; Heating;

DOI:10.1055/s-1993-25945

Reference yield: 85.0%

atranol (526-37-4) → 5-methylpyrogallol (609-25-6)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.3390/molecules23102619

Reference yield: 75.0%

5-methyl-2-(pyridin-2-yloxy)-1,3-phenylene diacetate → 5-methylpyrogallol (609-25-6)

Guidance literature:

5-methyl-2-(pyridin-2-yloxy)-1,3-phenylene diacetate; With methyl trifluoromethanesulfonate; In toluene; for 2h; Reflux;

With sodium methylate; In methanol; for 1h; Reflux;

upstream raw materials:

2,6-dimethoxy-4-methylphenol

3,4,5-trimethoxytoluene

3,4,5-triacetoxy-toluene

methyl 3-hydroxy orsellinate

Downstream raw materials:

3,4,5-triacetoxy-toluene

2-methoxy-5-methyl-resorcinol

3-methoxy-5-methylbenzene-1,2-diol

3,4,5-trimethoxytoluene

Refernces

• 1、 Cheng, Lu,Wang, Huihui,Cai, Hengrui,Zhang, Jie,Gong, Xu,Han, Wei. "Iron-catalyzed arene C-H hydroxylation". . p. 77 - 81. Retrieved 2021/10/05.
• 2、 Kamauchi, Hitoshi,Oda, Takumi,Horiuchi, Kanayo,Takao, Koichi,Sugita, Yoshiaki. "Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities". . . Retrieved 2019/11/26.