Technology Process of C15H16N2O4
There total 3 articles about C15H16N2O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,5-dimethoxyaniline;
With
hydrogenchloride; sodium nitrite;
In
tetrahydrofuran; water;
at 0 - 5 ℃;
2-methoxy-phenol;
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 5 ℃;
for 1h;
DOI:10.1016/j.bmcl.2012.10.050
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C
2.1: triethylamine; diphenyl phosphoryl azide / 80 °C
3.1: sodium hydroxide; benzoic acid / tetrahydrofuran / 0.5 h / 20 °C
4.1: sodium nitrite; hydrogenchloride / tetrahydrofuran; water / 0 - 5 °C
4.2: 1 h / 0 - 5 °C
With
hydrogenchloride; diphenyl phosphoryl azide; triethylamine; benzoic acid; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; water;
2.1: |Curtius Rearrangement / 3.1: |Curtius Rearrangement;
DOI:10.1016/j.bmcl.2012.10.050
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; diphenyl phosphoryl azide / 80 °C
2.1: sodium hydroxide; benzoic acid / tetrahydrofuran / 0.5 h / 20 °C
3.1: sodium nitrite; hydrogenchloride / tetrahydrofuran; water / 0 - 5 °C
3.2: 1 h / 0 - 5 °C
With
hydrogenchloride; diphenyl phosphoryl azide; triethylamine; benzoic acid; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; water;
1.1: |Curtius Rearrangement / 2.1: |Curtius Rearrangement;
DOI:10.1016/j.bmcl.2012.10.050