Technology Process of 5-[bis(4'-tert-butylbiphenyl-4-yl)amino]-2-nitrobenzoic acid
There total 4 articles about 5-[bis(4'-tert-butylbiphenyl-4-yl)amino]-2-nitrobenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
2-ethoxy-ethanol;
at 90 ℃;
for 0.5h;
DOI:10.1039/b916454e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate / toluene / 20 h / 80 °C / Inert atmosphere
2: water; sodium hydroxide / 2-ethoxy-ethanol / 0.5 h / Reflux
With
1,1'-bis-(diphenylphosphino)ferrocene; water; palladium diacetate; caesium carbonate; sodium hydroxide;
In
2-ethoxy-ethanol; toluene;
1: Hartwig-Buchwald cross coupling;
DOI:10.1002/chem.201103411
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine; thionyl chloride / 4 h / 0 °C / Inert atmosphere
2: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate / toluene / 20 h / 80 °C / Inert atmosphere
3: water; sodium hydroxide / 2-ethoxy-ethanol / 0.5 h / Reflux
With
pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; water; palladium diacetate; caesium carbonate; sodium hydroxide;
In
2-ethoxy-ethanol; toluene;
2: Hartwig-Buchwald cross coupling;
DOI:10.1002/chem.201103411