Technology Process of benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
There total 7 articles about benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jo201794k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
2.2: 40 h / -40 °C / Inert atmosphere
3.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
With
water; sodium hydride; sodium carbonate; sodium sulfite;
In
tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo201794k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
1.2: 40 h / -40 °C / Inert atmosphere
2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
water; sodium hydride; sodium carbonate; sodium sulfite;
In
tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo201794k