cabazitaxel Cbz-β-alanine glycolate

Base Information

• Chemical Name: cabazitaxel Cbz-β-alanine glycolate
• CAS No.: 1308398-71-1
• Molecular Formula: C₅₈H₇₀N₂O₁₉
• Molecular Weight: 1099.2
• Mol file: 1308398-71-1.mol

Synonyms:cabazitaxel Cbz-β-alanine glycolate

Chemical Property of cabazitaxel Cbz-β-alanine glycolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of cabazitaxel Cbz-β-alanine glycolate

There total 4 articles about cabazitaxel Cbz-β-alanine glycolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbazitaxel (183133-96-2,1714967-27-7) + 2-((3-(((benzyloxy)carbonyl)amino)propanoyl)oxy)acetic acid (205640-31-9) → cabazitaxel Cbz-β-alanine glycolate (1308398-71-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

carbazitaxel (183133-96-2,1714967-27-7) + 3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → cabazitaxel Cbz-β-alanine glycolate (1308398-71-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h; Product distribution / selectivity;

Reference yield:

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → cabazitaxel Cbz-β-alanine glycolate (1308398-71-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 16 h / 60 °C

2: formic acid / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With dmap; formic acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;

upstream raw materials:

carbazitaxel

3-(benzyloxycarbonylamino)propanoic acid

2-((3-(((benzyloxy)carbonyl)amino)propanoyl)oxy)acetic acid

Downstream raw materials:

cabazitaxel β-alanine glycolate methanesulfonate

Refernces

• 1、 -. "CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY". . . Retrieved 2011/06/19.