2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

Base Information Edit

Chemical Name:2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde
CAS No.:151052-40-3
Molecular Formula:C₁₄H₁₀N₄O
Molecular Weight:250.26
Hs Code.:
UNII:JR846PVT27
Nikkaji Number:J2.217.155K
Mol file:151052-40-3.mol

Synonyms:151052-40-3;4-[2-(2H-tetrazol-5-yl)phenyl]benzaldehyde;2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde;2'-(1H-Tetrazol-5-yl)-1,1'-biphenyl-4-carboxaldehyde (Losartan Impurity);2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde;JR846PVT27;SCHEMBL1561472;2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde;HQBRKMUDLIZVAS-UHFFFAOYSA-N;MFCD20483409;CS-0370584;C90689;2'-(1 H-tetrazol-5-yl)biphenyl-4-carbaldehyde;2'-(1H-tetrazol-5-yl)-biphenyl-4-carbaldehyde;2'-(1H-tetrazol-5-yl)-biphenyl-4carbal-dehyde;2'-(2H-Tetrazol-5-yl)-biphenyl-4-carbaldehyd;2'-(1H-tetrazol-5-yl)-biphenyl-4-carbal-dehyde;2'-(1h-tetrazol-5-yl)-1,1'-biphenyl-4-carboxaldehyde;2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde;2'-(2H-Tetrazol-5-yl)[1,1'-biphenyl]-4-carboxaldehyde;[1,1'-Biphenyl]-4-carboxaldehyde, 2'-(1H-tetrazol-5-yl)-;[1,1'-Biphenyl]-4-carboxaldehyde, 2'-(2H-tetrazol-5-yl)-

Suppliers and Price of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2''-(1H-Tetrazol-5-yl)-1,1''-biphenyl-4-carboxaldehyde(LosartanImpurity)
25mg
$ 1390.00

Medical Isotopes, Inc.
2??-(1H-Tetrazol-5-yl)-1,1??-biphenyl-4-carboxaldehyde(LosartanImpurity)
250 mg
$ 2200.00

Medical Isotopes, Inc.
2??-(1H-Tetrazol-5-yl)-1,1??-biphenyl-4-carboxaldehyde(LosartanImpurity)
25 mg
$ 650.00

Total 5 raw suppliers

Chemical Property of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde Edit

Chemical Property:

Melting Point:>176°C (dec.)
Boiling Point:516.3±60.0 °C(Predicted)
Density:1.319±0.06 g/cm3(Predicted)
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:250.08546096
Heavy Atom Count:19
Complexity:304

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2''-(1H-Tetrazol-5-yl)-1,1''-biphenyl-4-carboxaldehyde(LosartanImpurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC=C(C=C2)C=O)C3=NNN=N3
Uses 2''-(1H-Tetrazol-5-yl)-1,1''-biphenyl-4-carboxaldehyde is an impurity of Losartan Potassium (L470500), an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients.

Technology Process of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

There total 13 articles about 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 135689-93-9
4-(2-Cyanophenyl)benzaldehyde

: 151052-40-3
2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

Guidance literature:: With sodium azide; triethylamine hydrochloride; sodium nitrite; In acetic acid butyl ester; at 25 - 105 ℃; pH=4.3; Product distribution / selectivity;

Reference yield: 93.0%

: 135689-93-9
4-(2-Cyanophenyl)benzaldehyde

: 164265-78-5
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic acid

: 151052-40-3
2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

Guidance literature:: With sodium azide; triethylamine hydrochloride; In acetic acid butyl ester; at 105 ℃; Product distribution / selectivity;

Reference yield: 55.0%

: 73096-42-1
5-(2-bromophenyl)-1H-tetrazole

: 87199-17-5
4-formylphenylboronic acid,

: 18039-42-4,3999-10-8
5-Phenyl-1H-tetrazole

: 151052-40-3
2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 115 ℃; for 0.5h; microwave irradiation;
DOI:10.1016/j.tetlet.2005.07.082