Benzydamine

Base Information

• Chemical Name: Benzydamine
• CAS No.: 642-72-8
• Molecular Formula: C19H23 N3 O
• Molecular Weight: 309.411
• Hs Code.: 2933990090
• European Community (EC) Number: 211-388-8
• UNII: 4O21U048EF
• DSSTox Substance ID: DTXSID7047859
• Nikkaji Number: J7.060B
• Wikipedia: Benzydamine
• Wikidata: Q793143
• NCI Thesaurus Code: C83548
• Metabolomics Workbench ID: 152138
• ChEMBL ID: CHEMBL12610
• Mol file: 642-72-8.mol

Synonyms:Benzidamine;Benzindamine;Benzydamine;Benzydamine Hydrochloride;Benzydamine Monohydrochloride;Difflam;Hydrochloride, Benzydamine;Lonol;Monohydrochloride, Benzydamine;Novo Benzydamine;Novo-Benzydamine;Opalgyne;PMS Benzydamine;PMS-Benzydamine;ratio Benzydamine;ratio-Benzydamine;Rosalgin;Sun Benz;Sun-Benz;Tantum;Tantum Topico

Chemical Property of Benzydamine

Chemical Property:

• Vapor Pressure: 3.64E-09mmHg at 25°C
• Melting Point: 167-170 °C
• Refractive Index: 1.5900 (estimate)
• Boiling Point: 474.4oC at 760 mmHg
• PKA: 9.25±0.28(Predicted)
• Flash Point: 240.7oC
• PSA: 30.29000
• Density: 1.08g/cm3
• LogP: 3.41510
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 309.184112366
• Heavy Atom Count: 23
• Complexity: 344

Purity/Quality:

98%min ^*data from raw suppliers

Benzydamine ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
• Recent ClinicalTrials: Study for the Prevention of Oral Mucositis (SPOM)
• Recent EU Clinical Trials: Phase III study to evaluate the efficacy of a novel antimycotic vaginal pessary combination (containing Benzydamine HCl 6 mg and Econazole nitrate 150 mg) in the Treatment of uncomplicated vulvovaginal candidosis (VVC) [BEtreat study]
• Description: Benzydamine is an analytical reference standard categorized as an analgesic. Benzydamine has been abused and is associated with hallucinations, muscle weakness, and excitability. This product is intended for research and forensic applications.
• Uses: Benzydamine is a nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.

Technology Process of Benzydamine

There total 1 articles about Benzydamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ benzydamine (642-72-8)

Guidance literature:

1-Benzyl-(3-aminopropoxy)-1H-indazol + HCHO + HCO2H;

Reference yield: 100.0%

linoleic acid (60-33-3,116745-32-5,26085-09-6,64080-88-2,7049-66-3,949900-18-9,60476-23-5,6144-28-1,67922-65-0,89718-18-3) + benzydamine (642-72-8) → C19H23N3O*C18H32O2

Guidance literature:

In tetrahydrofuran; at 40 - 50 ℃; for 5h;

Reference yield: 100.0%

Octanoic acid (124-07-2) + benzydamine (642-72-8) → C19H23N3O*C8H16O2

Guidance literature:

In tetrahydrofuran; at 40 - 50 ℃; for 5h;

Downstream raw materials:

Phenylbutazon-Benzydamin-Salz

1-benzyl-3-hydroxy-1H-indazole

2-β-dimethylaminopropyl-1-benzylindalolin-3-one

Benzydamine N-Oxide