Phentolamine, methane sulfonate

Base Information

• Chemical Name: Phentolamine, methane sulfonate
• CAS No.: 65-28-1
• Molecular Formula: C18H23N3O4S
• Molecular Weight: 377.464
• Hs Code.: 29332900
• Mol file: 65-28-1.mol

Synonyms:Phentolamine, methane sulfonate

Chemical Property of Phentolamine, methane sulfonate

Chemical Property:

• Appearance/Colour: white to off-white crystalline solid
• Vapor Pressure: 9.48E-13mmHg at 25°C
• Melting Point: 180-182 °C
• Refractive Index: 1.6320 (estimate)
• Boiling Point: 551 °C at 760 mmHg
• Flash Point: 287 °C
• PSA: 110.61000
• Density: 1.2256 (rough estimate)
• LogP: 3.18960
• Storage Temp.: Refrigerator
• Solubility.: ethanol: 26 mg/mL
• Water Solubility.: 50 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 377.14092740
• Heavy Atom Count: 26
• Complexity: 442

Purity/Quality:

99% ^*data from raw suppliers

Phentolamine methanesulfonate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N(CC2=NCC[NH2+]2)C3=CC(=CC=C3)O.CS(=O)(=O)[O-]
• Uses: Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM Phentolamine Methanesulfonate Salt is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma. As an adrenergic blocking agent and an antihypertensive, Phentolamine mesilate can be used for the treatment of pheochromocytoma.
• Clinical Use: Alpha-adrenoceptor blocker: Hypertensive crisis
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Antidepressants: additive hypotensive effect with MAOIs - avoid. Antihypertensives: enhanced hypotensive effect. Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use. Diuretics: enhanced hypotensive effect. Linezolid: additive hypotensive effect. Moxisylyte: possibly severe postural hypotension.

Technology Process of Phentolamine, methane sulfonate

There total 1 articles about Phentolamine, methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanesulfonic acid (75-75-2,98527-29-8) + phentolamine (50-60-2) → phentolamine mesylate (65-28-1)

Guidance literature:

In ethanol; pH=5 - 6;

Reference yield: 33.0%

N-(quinolin-8-yl)but‐3‐enamide + phentolamine mesylate (65-28-1) → 2-(((3-hydroxy-4-(4-oxo-4-(quinolin-8-ylamino)butyl)phenyl)(p-tolyl)amino)methyl)-4,5-dihydro-1Himidazol-3-ium acetate

Guidance literature:

With palladium diacetate; acetic acid; In acetonitrile; at 120 ℃; for 4h;

DOI:10.1021/jacs.6b08850

upstream raw materials:

methanesulfonic acid

phentolamine

Refernces