1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione

Base Information

• Chemical Name: 1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione
• CAS No.: 3363-97-1
• Molecular Formula: C22H14O4
• Molecular Weight: 342.351
• Hs Code.: 2914399090
• Mol file: 3363-97-1.mol

Synonyms:Ethanedione,1,1'-(1,4-phenylene)bis[2-phenyl- (9CI);Glyoxal, p-phenylenebis[phenyl-(7CI,8CI);1,4-Bis(2-phenyl-1,2-dioxoethyl)benzene;1,4-Bis(phenylglyoxalyl)benzene;1,4-Bis(phenylglyoxyloyl)benzene;1,4-Bis(phenylglyoxylyl)benzene;2,2'-Diphenyl-1,1'-(1,4-phenylene)diethanedione;NSC 379518;p-(Phenylglyoxyloyl)benzil;p-Bis(phenylglyoxaloyl)benzene;p-Bis(phenylglyoxalyl)benzene;p-Bis(phenylglyoxyloyl)benzene;p-Di(phenylglyoxalyl)benzene;

Chemical Property of 1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione

Chemical Property:

• Vapor Pressure: 4.22E-12mmHg at 25°C
• Melting Point: 125°C
• Refractive Index: 1.627
• Boiling Point: 549 °C at 760 mmHg
• Flash Point: 237.7 °C
• PSA: 68.28000
• Density: 1.261 g/cm³
• LogP: 3.81780

Purity/Quality:

99% ^*data from raw suppliers

1,4-Bisbenzil >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione

There total 19 articles about 1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-bis(2-phenylethynyl)benzene (1849-27-0) → 1,4-bis(phenylglyoxalyl)benzene (3363-97-1)

Guidance literature:

With iodine; In dimethyl sulfoxide;

DOI:10.1007/BF00698465

Reference yield: 74.0%

1-((E)-2-(cyclohexa-1,5-dien-1-yl)vinyl)-4-((E)-styryl)benzene → 1,4-bis(phenylglyoxalyl)benzene (3363-97-1)

Guidance literature:

With tert.-butylhydroperoxide; water; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 90 ℃; for 24h;

DOI:10.1021/acscatal.9b05197

Reference yield: 73.0%

1,4-Diacetylbenzene (1009-61-6) + benzaldehyde (100-52-7) → 1,4-bis(phenylglyoxalyl)benzene (3363-97-1)

Guidance literature:

With water; dihydrogen peroxide; sodium hydroxide; at 50 ℃; for 10h; Inert atmosphere; Sealed tube; Schlenk technique; Glovebox; Green chemistry;

DOI:10.1039/d0gc03739g

upstream raw materials:

p-bis(phenacyl)benzene

1,4-bis(2-phenylethynyl)benzene

1,4-bis(5-phenyl-2,4,6,8-tetraaza-3,7-dioxobicyclo<3.3.0>octan-1-yl)benzene

1,4-bis (phenylacetyl)benzene

Downstream raw materials:

1-(carboxyhydroxyphenylmethyl)-4-(2-phenyl-1,2-dioxoethyl)benzene

1,4-di(carboxyhydroxyphenylmethyl)benzene

1-<4-(1,2-dihydroxy-2-phenylethyl)phenyl>-2-phenylethane-1,2-dione

1,4-Bis(1,2-dihydroxy-2-phenylethyl)benzene

Refernces

• 1、 Dubovtsev, Alexey Yu.,Shcherbakov, Nikolay V.,Dar'in, Dmitry V.,Kukushkin, Vadim Yu.. "Nature of the Nucleophilic Oxygenation Reagent Is Key to Acid-Free Gold-Catalyzed Conversion of Terminal and Internal Alkynes to 1,2-Dicarbonyls". . p. 745 - 757. Retrieved 2020/02/04.
• 2、 -. "Method for synthesizing benzil derivatives". Paragraph 0114; 0115; 0116; 0117; 0118. . Retrieved 2019/01/23.