4-chlorosalicylate

Base Information

• Chemical Name: 4-chlorosalicylate
• CAS No.: 45866-17-9
• Molecular Formula: C₇H₄ClO₃
• Molecular Weight: 171.56
• Mol file: 45866-17-9.mol

Synonyms:4-chlorosalicylate

Chemical Property of 4-chlorosalicylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chlorosalicylate

There total 7 articles about 4-chlorosalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) → 4-chlorosalicylate (45866-17-9)

Guidance literature:

With cetyltrimethylammonium bromide; In water; at 30 ℃; Rate constant; protolysis studied by the ultrasonic absorption method; pK_a; the volume change of the reaction;

DOI:10.1039/ft9949000869

Reference yield:

2-acetoxy-5-chloro-benzoic acid (1734-62-9) + α-cyclodextrin (10016-20-3,123880-20-6,150521-49-6) → 4-chlorosalicylate (45866-17-9) + C38H62O31

Guidance literature:

In methanol; at 25 ℃; Mechanism; Rate constant; also with β-cyclodextrin;

DOI:10.1021/jo00298a042

Reference yield:

2-carboxy-4-chlorophenyl propanoate (1760-88-9) + α-cyclodextrin (10016-20-3,123880-20-6,150521-49-6) → 4-chlorosalicylate (45866-17-9) + C39H64O31

Guidance literature:

In methanol; at 25 ℃; Mechanism; Rate constant; also with β-cyclodextrin;

DOI:10.1021/jo00298a042

upstream raw materials:

5-chloro-2-hydroxybenzoic acid

2-acetoxy-5-chloro-benzoic acid

α-cyclodextrin

2-carboxy-4-chlorophenyl propanoate

Downstream raw materials:

5-chloro-2-hydroxybenzoic acid

Refernces

• 1、 Isoda, Teruyo,Yamasaki, Miyuki,Yano, Hiroshige,Sano, Takayuki,Harada, Shoji. "Cationic Micellar Effect on the Kinetics of the Protolysis of Aromatic Carboxylic Acids studied by the Ultrasonic Absorption Method". . p. 869 - 874. Retrieved 2007/10/02.
• 2、 Pandey, Ashok Kumar,Chandra, M.,Agarwala, B. V.,Dey, A. K.. "Binary and Ternary Chelates of Scandium(III), Yttrium(III) and Lanthanum(III) with Ethyleneglycol-Bis(β-Aminoethylether)-Tetraacetic Acid as Primary and Substituted Salicylic Acids as Secondary Ligands". . p. 32 - 34. Retrieved 2007/10/02.