Zardaverine

Base Information

• Chemical Name: Zardaverine
• CAS No.: 101975-10-4
• Molecular Formula: C12H10F2N2O3
• Molecular Weight: 268.22
• UNII: TQ358GWH6Y
• DSSTox Substance ID: DTXSID8042559
• Nikkaji Number: J326.154I
• Wikipedia: Zardaverine
• Wikidata: Q15634082
• NCI Thesaurus Code: C66686
• Pharos Ligand ID: V3D9PUHH287C
• Metabolomics Workbench ID: 56661
• ChEMBL ID: CHEMBL313842
• Mol file: 101975-10-4.mol

Synonyms:6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)pyridazinone;zardaverine

Chemical Property of Zardaverine

Chemical Property:

• Refractive Index: 1.554
• PKA: 10.89±0.40(Predicted)
• PSA: 64.21000
• Density: 1.38 g/cm³
• LogP: 2.04690
• Storage Temp.: Store at RT
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 268.06594851
• Heavy Atom Count: 19
• Complexity: 398

Purity/Quality:

98%min ^*data from raw suppliers

Zardaverine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F
• Uses: Bronchodilator;Phosphodiesterase III inhibitor Zardaverine can selectively inhibit?phosphodiesterase III (PDE III) from human platelets and?phosphodiesterase IV (PDE IV) from human polymorphonuclear leucocytes (PMN).
• Therapeutic Function: Bronchodilator, Anti-asthmatic

Technology Process of Zardaverine

There total 1 articles about Zardaverine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 1-(4-(difluoromethoxy)-3-methoxyphenyl)ethan-1-one (101975-20-6) + zardaverine (101975-10-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water;

upstream raw materials:

1-(3-methoxy-4-hydroxyphenyl)ethanone

Refernces