2-methoxy-9-p-toluenesulfonylcarbazole

Base Information

• Chemical Name: 2-methoxy-9-p-toluenesulfonylcarbazole
• CAS No.: 1174643-97-0
• Molecular Formula: C₂₀H₁₇NO₃S
• Molecular Weight: 351.426
• Mol file: 1174643-97-0.mol

Synonyms:2-methoxy-9-p-toluenesulfonylcarbazole

Chemical Property of 2-methoxy-9-p-toluenesulfonylcarbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-9-p-toluenesulfonylcarbazole

There total 5 articles about 2-methoxy-9-p-toluenesulfonylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.66%

3-methoxydibenzo[b,d]iodol-5-ium trifluoromethanesulfonate (1469876-11-6) + toluene-4-sulfonamide (70-55-3) → 2-methoxy-9-p-toluenesulfonylcarbazole (1174643-97-0)

Guidance literature:

With copper diacetate; sodium carbonate; In ethylene glycol; isopropyl alcohol; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.07.029

Reference yield: 82.0%

N-(4'-methoxybiphenyl-2-yl)-4-methylbenzenesulfonamide → 2-methoxy-9-p-toluenesulfonylcarbazole (1174643-97-0)

Guidance literature:

With Oxone; palladium diacetate; toluene-4-sulfonic acid; Trimethylacetic acid; In N,N-dimethyl-formamide; at 25 ℃; for 9h;

DOI:10.1021/ol201416u

Reference yield: 75.0%

N-Ts-2-(3'-methoxyphenyl)aniline (1312447-94-1) → 2-methoxy-9-p-toluenesulfonylcarbazole (1174643-97-0)

Guidance literature:

With lithium perchlorate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 3h; Electrolysis; Inert atmosphere;

DOI:10.1002/cjoc.202000407

upstream raw materials:

1-methoxy-1,3-cyclohexadiene

2-methoxy-1,3-cyclohexadiene

3-nitro-1-(p-toluenesulfonyl)indole

3-methoxydibenzo[b,d]iodol-5-ium trifluoromethanesulfonate

Refernces

• 1、 Zhu, Daqian,Chen, Meihui,Li, Min,Luo, Bingling,Zhao, Yang,Huang, Peng,Xue, Fengtian,Rapposelli, Simona,Pi, Rongbiao,Wen, Shijun. "Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity". . p. 81 - 88. Retrieved 2013/10/01.
• 2、 Youn, So Won,Bihn, Joon Hyung,Kim, Byung Seok. "Pd-catalyzed intramolecular oxidative C-H amination: Synthesis of carbazoles". supporting information; experimental part. p. 3738 - 3741. Retrieved 2011/09/13.