diethyl (4-methylbenzene-1,3-diyl)biscarbamate

Base Information

• Chemical Name: diethyl (4-methylbenzene-1,3-diyl)biscarbamate
• CAS No.: 7450-62-6
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.297
• Mol file: 7450-62-6.mol

Synonyms:

Chemical Property of diethyl (4-methylbenzene-1,3-diyl)biscarbamate

Chemical Property:

• Vapor Pressure: 0.000774mmHg at 25°C
• Boiling Point: 306.4°C at 760 mmHg
• Flash Point: 139.1°C
• Density: 1.223g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl (4-methylbenzene-1,3-diyl)biscarbamate

There total 23 articles about diethyl (4-methylbenzene-1,3-diyl)biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 2,4-Toluene diisocyanate (584-84-9,6144-18-9,26006-20-2) → 2,4-bis-(ethoxycarbonylamino)toluene (7450-62-6)

Guidance literature:

With MoCl₂O₂(dmf)2; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201200303

Reference yield: 98.0%

4-methylbenzene-1,3-diamine (95-80-7,71111-07-4) + chloroformic acid ethyl ester (541-41-3) → 2,4-bis-(ethoxycarbonylamino)toluene (7450-62-6)

Guidance literature:

With TEA; In tetrahydrofuran; for 1h; Heating;

DOI:10.1016/j.tet.2006.09.103

Reference yield: 97.0%

4-methylbenzene-1,3-diamine (95-80-7,71111-07-4) + Diethyl carbonate (105-58-8,76619-83-5) → 2,4-bis-(ethoxycarbonylamino)toluene (7450-62-6)

Guidance literature:

Zn₄O(OAc)6; at 190 ℃; for 4.91667h; Inert atmosphere; Autoclave;

upstream raw materials:

ethanol

(3-isocyanato-4-methyl-phenyl)-carbamic acid ethyl ester

4-methylbenzene-1,3-diamine

chloroformic acid ethyl ester

Downstream raw materials:

2,4-Toluene diisocyanate

ethanol

1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)

2,4-tolylene diurea

Refernces

• 1、 Wang, Peixue,Ma, Yubo,Liu, Shimin,Zhou, Feng,Yang, Benqun,Deng, Youquan. "N-Substituted carbamate synthesis using urea as carbonyl source over TiO2-Cr2O3/SiO2 catalyst". . p. 3964 - 3971. Retrieved 2015/07/15.
• 2、 -. "ONE-POT PRODUCTION OF CARBAMATES USING SOLID CATALYSTS". Page/Page column 5. . Retrieved 2012/02/04.