1-(2-Aminophenyl)ethanol

Base Information

• Chemical Name: 1-(2-Aminophenyl)ethanol
• CAS No.: 941706-81-6
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• European Community (EC) Number: 234-052-2
• DSSTox Substance ID: DTXSID10909373
• Nikkaji Number: J212.442D
• Mol file: 941706-81-6.mol

Synonyms:1-(2-aminophenyl)ethanol;10517-50-7;1-(2-aminophenyl)ethan-1-ol;2-Amino-alpha-methylbenzyl alcohol;EINECS 234-052-2;MFCD12198838;1-(2-amino-phenyl)-ethanol;1-(aminophenyl)ethanol;2-(1-hydroxyethyl)aniline;methyl-2-aminophenyl carbinol;SCHEMBL129026;DTXSID10909373;AKOS010291739;AS-31317;SY005046;A3220;CS-0131935;FT-0765289;EN300-52136;A801157;Z734526976

Chemical Property of 1-(2-Aminophenyl)ethanol

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1N)O

Technology Process of 1-(2-Aminophenyl)ethanol

There total 14 articles about 1-(2-Aminophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-aminoacetophenone (551-93-9) → 1-(2-aminophenyl)ethanol (941706-81-6)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In methanol; at 20 ℃;

DOI:10.1039/c5cc10460b

Reference yield: 95.0%

2-acetylnitrobenzene (577-59-3) → 1-(2-aminophenyl)ethanol (941706-81-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 45 ℃; for 2h; Green chemistry;

DOI:10.1002/aoc.4132

Reference yield: 77.0%

(1'RS,αRS)-1'-[2-N-(α-methylbenzyl)aminophenyl]ethanol → 1-(2-aminophenyl)ethanol (941706-81-6)

Guidance literature:

With palladium hydroxide, 20 wt% on carbon; hydrogen; In ethanol; at 30 ℃; for 48h; under 3800.26 Torr;

DOI:10.1016/j.tet.2018.08.033

upstream raw materials:

2-acetylnitrobenzene

2-aminoacetophenone

N-[2-(1-hydroxyethyl)phenyl]formamide

Phthalsaeure-((+/-)-1-(o-nitro-phenyl)-ethylester)

Downstream raw materials:

2,4-dimethylquinoline-3-carboxylic acid ethyl ester

methyl 2,4-dimethylquinoline-3-carboxylate

indole

4-methyl-2-phenylquinoline

Refernces

• 1、 da Costa, M. Rute G.,Curto, M. Jo?o M.,Davies, Stephen G.,Teixeira, Fátima C.,Thomson, James E.. "Asymmetric synthesis of secondary benzylic alcohols via arene chromium tricarbonyl complexes". . p. 5965 - 5973. Retrieved 2018.
• 2、 Krishnan, Saravanan,Patel, Paresh N.,Balasubramanian, Kalpattu K.,Chadha, Anju. "Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines". supporting information. p. 1915 - 1923. Retrieved 2021/02/06.
• 3、 Alsalahi, W.,Trzeciak, A. M.,Tylus, W.. "Highly selective hydrogenation of aromatic ketones to alcohols in water: effect of PdO and ZrO2". . p. 10386 - 10393. Retrieved 2021/08/09.