Technology Process of methyl 1-[(benzylcarbamoylmethyl)methylamino]-6,8-dichloro-isoquinoline-3-carboxylate
There total 10 articles about methyl 1-[(benzylcarbamoylmethyl)methylamino]-6,8-dichloro-isoquinoline-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-benzyl-2-methylaminoacetamide trifluoroacetate;
With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
for 0.0333333h;
methyl 1,6,8-trichloro-isoquinoline-3-carboxylate;
In
dimethyl sulfoxide;
at 95 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / 3 h / 20 - 40 °C / Cooling with ice
2.1: ammonium carbonate; acetic acid / 14 h / 95 °C / Inert atmosphere
3.1: trichlorophosphate / 8 h / 100 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.03 h
4.2: 20 h / 95 °C
With
thionyl chloride; ammonium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium hydroxide / ethanol; water / 45 h / 110 °C
2.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C
3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 17 h / Reflux
4.1: lithium hydroxide monohydrate / water / 4 h / Reflux
5.1: 24 h / 20 °C
6.1: hydrogenchloride / water; acetic acid / 3 h / 100 °C
7.1: thionyl chloride / 3 h / 20 - 40 °C / Cooling with ice
8.1: ammonium carbonate; acetic acid / 14 h / 95 °C / Inert atmosphere
9.1: trichlorophosphate / 8 h / 100 °C / Inert atmosphere
10.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.03 h
10.2: 20 h / 95 °C
With
hydrogenchloride; N-Bromosuccinimide; thionyl chloride; lithium hydroxide monohydrate; sulfuric acid; ammonium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium nitrite; trichlorophosphate; dibenzoyl peroxide;
In
tetrachloromethane; ethanol; water; acetic acid; dimethyl sulfoxide;
