3-(3-benzoylphenyl)butan-2-one

Base Information

• Chemical Name: 3-(3-benzoylphenyl)butan-2-one
• CAS No.: 79868-87-4
• Molecular Formula: C₁₇H₁₆O₂
• Molecular Weight: 252.313
• Mol file: 79868-87-4.mol

Synonyms:3-(3-benzoylphenyl)butan-2-one

Chemical Property of 3-(3-benzoylphenyl)butan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(3-benzoylphenyl)butan-2-one

There total 5 articles about 3-(3-benzoylphenyl)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ketoprofen chloride (59512-44-6,71381-92-5,109718-56-1) + trimethyl orthoformate (149-73-5) → 3-(3-benzoylphenyl)butan-2-one (79868-87-4)

Guidance literature:

With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N¹,N¹]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 20 ℃; for 48h; Irradiation; Sealed tube;

DOI:10.1021/jacs.0c02805

Reference yield:

3-bromobenzophenone (1016-77-9) → 3-(3-benzoylphenyl)butan-2-one (79868-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CuBr / dimethylformamide / 7.5 h / 100 - 120 °C

copper(I) bromide; In N,N-dimethyl-formamide;

DOI:10.1246/cl.1982.597

Reference yield:

ketoprofen (22071-15-4,22161-86-0) → 3-(3-benzoylphenyl)butan-2-one (79868-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2: [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N¹,N¹]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; [nickel(II)dichloride(dimethoxyethane)]; potassium phosphate; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 48 h / 20 °C / Irradiation; Sealed tube

With potassium phosphate; oxalyl dichloride; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N¹,N¹]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; N,N-dimethyl-formamide; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; benzene;

DOI:10.1021/jacs.0c02805

upstream raw materials:

1-(3-benzoylphenyl)-2-propanone

methyl iodide

3-chlorobenzophenone

acetone

Downstream raw materials:

ketoprofen

Refernces

• 1、 Kariofillis, Stavros K.,Shields, Benjamin J.,Tekle-Smith, Makeda A.,Zacuto, Michael J.,Doyle, Abigail G.. "Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source". . p. 7683 - 7689. Retrieved 2020/04/22.