5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine

Base Information

• Chemical Name: 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine
• CAS No.: 114460-18-3
• Molecular Formula: C₂₀H₂₄N₂O
• Molecular Weight: 308.423
• Mol file: 114460-18-3.mol

Synonyms:5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine

Chemical Property of 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine

There total 3 articles about 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-chloronicotinonitrile (33252-28-7) + 2,6-di-tert-butylphenol (128-39-2) → 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine (114460-18-3)

Guidance literature:

With potassium tert-butylate; phthalonitrile; In ammonia; at -38 ℃; electrosynthesis: cathode - platinum grid, 10 cm², 1024 mesh/cm²; anode - magnesium rod, h = 8 cm, Φ = 1 cm; constant current density 0,5 A dm^-2, KBr as supporting electrolyte;

DOI:10.1021/jo00095a024

Reference yield:

6-chloronicotinonitrile (33252-28-7) + potassium 2,6-di-tert-butylphenolate (24676-69-5) → 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine (114460-18-3)

Guidance literature:

With phthalonitrile; In ammonia; at -38 ℃; Rate constant; Ag/Ag⁽¹⁺⁾, 3.5 cm² platinum grid (1024 mesh per cm²);

DOI:10.1021/jo00313a022

Reference yield:

6-chloronicotinonitrile (33252-28-7) + 2,6-di-tert-butylphenoxide anion (52977-87-4) → 5-cyano-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)pyridine (114460-18-3) + 6-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-1-oxy-nicotinonitrile

Guidance literature:

Product distribution; Mechanism; Irradiation; other methods instead of photolysis;

DOI:10.1039/c39880000203

upstream raw materials:

6-chloronicotinonitrile

2,6-di-tert-butylphenol

potassium 2,6-di-tert-butylphenolate

2,6-di-tert-butylphenoxide anion

Refernces

• 1、 Alam, N.,Amatore, C.,Combellas, C.,Thiebault, A.,Verpeaux, J. N.. "Theory and Experimental Illustration of Preparative Electrochemistry Using Redox Catalysis of Electron Transfer Initiated Radical Chain Reactions. Application to the Cross-Coupling between Aryl Halides and Phenoxide Ions". . p. 6347 - 6356. Retrieved 2007/10/02.