Technology Process of 4-(5-chloro-2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide
There total 13 articles about 4-(5-chloro-2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex;
In
1,4-dioxane; water;
at 120 ℃;
for 0.5h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 56 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 °C / Inert atmosphere; Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 20 - 30 °C / Inert atmosphere
4.1: Oxone.(R). / methanol; water / 0 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane; water / 20 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
6.2: 20 °C / Inert atmosphere
7.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
8.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
With
hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; hydroxylamine hydrochloride; potassium acetate; sodium acetate; triethylamine; sodium hydroxide;
2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 °C / Inert atmosphere; Reflux
2.1: sodium hydroxide / 1,4-dioxane; water / 20 - 30 °C / Inert atmosphere
3.1: Oxone.(R). / methanol; water / 0 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane; water / 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
7.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
With
hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; potassium acetate; triethylamine; sodium hydroxide;
2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;