Technology Process of 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
There total 13 articles about 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
at 80 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 140 °C
2.1: hydrazine / ethanol / 72 h / 20 °C
3.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C
3.2: 0.25 h / 0 °C
3.3: pH 7
4.1: pyridine / 4.08 h / 0 - 20 °C
5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 4 h / 80 °C
With
pyridine; boron tribromide; sodium carbonate; triethylamine; hydrazine;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 17 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -67 °C
2.2: 3 h / -78 °C
3.1: water; toluene-4-sulfonic acid / acetone / 24 h / 20 °C
3.2: 1 h / 45 °C
4.1: triethylamine / 140 °C
5.1: hydrazine / ethanol / 72 h / 20 °C
6.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C
6.2: 0.25 h / 0 °C
6.3: pH 7
7.1: pyridine / 4.08 h / 0 - 20 °C
8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 4 h / 80 °C
With
pyridine; water; boron tribromide; sodium tris(acetoxy)borohydride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; hydrazine; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone;