4-Ethylpyridin-2-amine

Base Information

• Chemical Name: 4-Ethylpyridin-2-amine
• CAS No.: 33252-32-3
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 251-430-2
• UNII: 5WXK5F5SZY
• DSSTox Substance ID: DTXSID00186898
• Nikkaji Number: J319.516C
• Wikidata: Q72436932
• Pharos Ligand ID: 34D2SLUUM98X
• ChEMBL ID: CHEMBL62077
• Mol file: 33252-32-3.mol

Synonyms:2-Amino-4-Ethylpyridine;4-Ethylpyridin-2-amine;33252-32-3;4-Ethyl-pyridin-2-ylamine;2-Pyridinamine, 4-ethyl-;4-Ethyl-2-pyridinamine;EINECS 251-430-2;MFCD00129025;CHEMBL62077;4-ethyl-2-aminopyridine;5WXK5F5SZY;SCHEMBL91489;DTXSID00186898;BCP14171;BDBM50091813;2-Amino-4-ethylpyridine, AldrichCPR;AKOS009159093;CS-W007772;SB40538;SY008921;TS-01620;A5936;FT-0618423;EN300-96440;P17120;Q-101982

Chemical Property of 4-Ethylpyridin-2-amine

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.0345mmHg at 25°C
• Melting Point: 50-52 °C
• Refractive Index: 1.56
• Boiling Point: 242.153 °C at 760 mmHg
• PKA: 7.29±0.11(Predicted)
• Flash Point: 123.479 °C
• PSA: 38.91000
• Density: 1.037 g/cm³
• LogP: 1.80740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Hexane, Ethyl Acetate, Methyl tert-Butyl Ether
• Water Solubility.: Soluble in water, hexane, ethyl acetate and methyl tert-butyl ether.
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4-ethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22-41-37/38-22
• Safety Statements: 26-36/37/39-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=NC=C1)N
• Uses: An analogue of pirlimycin, an antibiotic 2-Amino-4-ethylpyridine is used as a precursor to prepare 1-ethyl-3-[5-(7-ethyl-imidazo[1,2-a]pyridin-2-yl)-2-hydroxy-phenyl]-urea. It is also used as an intermediate in organic synthesis. It is considered as an analogue of pirlimycin, which acts as an antibiotic.

Technology Process of 4-Ethylpyridin-2-amine

There total 10 articles about 4-Ethylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-vinylpyridin-2-amine (102000-55-5) → 4-ethylpyridin-2-amine (33252-32-3)

Guidance literature:

With palladium on activated charcoal; hydrogen;

Reference yield: 95.0%

N-(4-ethylpyridin-2-yl)picolinamide → 4-ethylpyridin-2-amine (33252-32-3)

Guidance literature:

N-(4-ethylpyridin-2-yl)picolinamide; With hydrogenchloride; In water; at 20 ℃; for 0.0833333h; Inert atmosphere;

With zinc; In water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.05.068

Reference yield: 90.0%

2-(2,5-dimethylpyrrol-1-yl)-4-ethylpyridine (95337-79-4) → 4-ethylpyridin-2-amine (33252-32-3)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; for 24h; Heating;

upstream raw materials:

4-Ethylpyridine

2-(2,5-dimethylpyrrol-1-yl)-4-ethylpyridine

4-ethylpyridine-1-oxide

2-Amino-4-methylpyridine

Downstream raw materials:

2-(4-bromophenyl)-7-ethylimidazo[1,2-a]pyridine hydrobromide

2-[(E)-2-(3-Benzyloxy-4-nitro-phenyl)-vinyl]-7-ethyl-3-methyl-imidazo[1,2-a]pyridine

1-Ethyl-3-[5-(7-ethyl-imidazo[1,2-a]pyridin-2-yl)-2-hydroxy-phenyl]-urea

2-bromo-4-ethylpyridine

Refernces

• 1、 O'Donovan, Daniel H.,De Fusco, Claudia,Spring, David R.. "The reductive cleavage of picolinic amides". supporting information. p. 2962 - 2964. Retrieved 2016/07/06.
• 2、 Hagmann,Caldwell,Chen,Durette,Esser,Lanza,Kopka,Guthikonda,Shah,MacCoss,Chabin,Fletcher,Grant,Green,Humes,Kelly,Luell,Meurer,Moore,Pacholok,Pavia,Williams,Wong. "Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.". . p. 1975 - 1978. Retrieved 2007/10/03.