(S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt

Base Information

• Chemical Name: (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt
• CAS No.: 84580-08-5
• Molecular Formula: C₈H₉Cl₂N*C₁₀H₁₆O₄S
• Molecular Weight: 422.373
• Mol file: 84580-08-5.mol

Synonyms:(S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt

Chemical Property of (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt

There total 3 articles about (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) + (+/-)-α-(3,5-dichlorophenyl)ethylamine (84499-83-2) → (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt (84580-08-5)

Guidance literature:

In methanol; Heating;

DOI:10.1021/ja00344a026

Reference yield:

3,5-dichlorobenzoic acid (51-36-5) → (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt (84580-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 10.5 g / tetrahydrofuran; diethyl ether / 1.) 0 deg C, 10 min, 2.) 30 min

2: 1.) formic acid, formamide, 2.) 3 N hydrochloric acid / 1.) H₂O, 165-180 deg C, 20 h, 2.) reflux, 48 h

3: 16 percent / methanol / Heating

With hydrogenchloride; formic acid; formamide; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/ja00344a026

Reference yield:

3',5'-dichloroacetophenone (14401-72-0) → (S)-α-(3,5-dichlorophenyl)ethylamine (+)-10-camphorsulfonic acid salt (84580-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) formic acid, formamide, 2.) 3 N hydrochloric acid / 1.) H₂O, 165-180 deg C, 20 h, 2.) reflux, 48 h

2: 16 percent / methanol / Heating

With hydrogenchloride; formic acid; formamide; In methanol;

DOI:10.1021/ja00344a026

upstream raw materials:

(1S)-10-camphorsulfonic acid

(+/-)-α-(3,5-dichlorophenyl)ethylamine

3,5-dichlorobenzoic acid

3',5'-dichloroacetophenone

Downstream raw materials:

(S)-α-(3,5-dichlorophenyl)ethylamine

Refernces